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Study Unveils Mucus Molecules That Block Salmonella and Prevent Diarrhea

A new MIT-led study reveals how key mucus molecules naturally shield the gut from dangerous bacteria like Salmonella

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Researchers have uncovered how mucins in digestive tract mucus can block the infection-causing abilities of Salmonella bacteria (shown in purple). Credit: Courtesy of the researchers

A new MIT-led study reveals how key mucus molecules naturally shield the gut from dangerous bacteria like Salmonella. The breakthrough opens new pathways for affordable, preventative treatments for travelers and soldiers at risk of infection.

Researchers at MIT have discovered new powerful ways the body guards itself from dangerous bacteria: by deploying mucins, special molecules in mucus that neutralize microbes and stop infection before it starts. The team identified mucins—especially MUC2 and MUC5AC—in the digestive tract that shut down the genetic machinery Salmonella uses to invade cells and cause diarrhea.

“By using and reformatting this motif from the natural innate immune system, we hope to develop strategies to preventing diarrhea before it even starts. This approach could provide a low-cost solution to a major global health challenge that costs billions annually in lost productivity, health care expenses, and human suffering,” said Katharina Ribbeck, the Andrew and Erna Viterbi Professor of Biological Engineering at MIT, in a media statement.

In experiments, exposing Salmonella to the intestinal mucin MUC2 blocked the bacterial proteins that enable infection, turning off the critical regulator HilD. The study also found that a similar mucin from the stomach, MUC5AC, works the same way—and both molecules appear to protect against multiple foodborne germs triggered by similar genetic switches.

“We discovered that these mucins not only create a physical shield but also actively control whether pathogens can turn on genes needed for infection,” Ribbeck explained in the media statement.

Lead authors Kelsey Wheeler and Michaela Gold say synthetic versions of these mucins could soon be added to oral rehydration salts or chewable tablets, providing practical protection for troops, travelers, and people in high-risk areas. According to Wheeler, “Mucin mimics would particularly shine as preventatives, because that’s how the body evolved mucus — as part of this innate immune system to prevent infection,” she said.

EP Staff is the editorial team at EdPublica, an independent media organisation focused on science, education, environment and public policy. The team produces evidence-based news, features, explainers and analysis on issues that shape society and everyday life.

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When Health Care Becomes a Target, Patients Pay the Price

WHO has recorded 914 attacks on health care in 2026, killing 911 people and injuring 1,486 across 19 countries and territories. Since 2017, more than 10,400 attacks have been documented, highlighting the growing risks to health workers, patients and essential medical services during conflict.

Vaishnavi V S

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Health worker holding a stethoscope, illustrating risks faced by medical professionals during attacks on health care
Health workers can become targets during conflict, putting essential medical services and patients at risk. Representational image. Image credit: Felipe Queiroz/Pexels

Health workers are expected to move towards people in danger. In many conflict zones, that same act of providing care is putting them in danger. The World Health Organization (WHO) recorded 914 attacks on health care in 2026 so far, resulting in 911 deaths and 1,486 injuries across 19 countries and territories. Most of the reported attacks have occurred in Ukraine, Lebanon, the occupied Palestinian territory and Myanmar.

The figures were released around World Humanitarian Day on August 19, when WHO renewed its call for health workers, patients, medical facilities and ambulances to be protected during conflicts. Since WHO began systematically documenting attacks on health care in December 2017, it has recorded more than 10,400 attacks across 29 countries and territories, resulting in more than 5,700 deaths and 8,500 injuries.

The numbers represent more than attacks on individual doctors or hospitals. When a health centre is bombed, an ambulance is stopped or a health worker is threatened, people who may never have been involved in the conflict can lose access to essential treatment.

What Counts as an Attack on Health Care?

WHO’s surveillance system covers violence, threats, obstruction and other acts that interfere with the availability, access or delivery of health services during emergencies. The attacks can affect health workers, patients, facilities and medical transport. That means the damage is not limited to deaths and injuries.

A damaged hospital may lose operating rooms, beds, medicines or electricity. An ambulance that cannot safely reach a patient can turn a treatable emergency into a fatal one. Health workers may leave areas where they no longer feel safe, leaving communities with fewer doctors and nurses.

Health care and infrastructure destruction in conflict zones.
War-damaged buildings line a street, illustrating the destruction and disruption that conflict can cause to communities and essential health care services. Representational image. Image credit: Baraa Obied/Pexels

A systematic review of research on attacks on health care in conflict found that these attacks can include bombing, looting, burning, occupation and obstruction of facilities, as well as threats, detention and physical attacks against health workers and patients. The researchers also noted significant gaps in documentation, making the available numbers likely to represent only part of the problem. WHO’s earlier analysis of attacks in fragile and conflict-affected settings similarly found that attacks reduce health-care capacity and interrupt services, affecting vulnerable populations long after the immediate incident.

The Effects Continue After the Attack

The loss of a health worker has consequences beyond the individual. A systematic mapping of 474 studies on health workers in conflict and post-conflict settings found evidence of threats, detention and killings, as well as health-worker displacement. In some conflicts, large numbers of medical professionals have left affected areas, contributing to shortages that persist after the fighting subsides.

This creates a cycle: conflict increases the need for medical care while simultaneously making it harder to provide that care. The consequences can extend to routine services such as maternal care, childhood immunisation and treatment for chronic diseases. A health system weakened by attacks may also be less prepared for disease outbreaks and other emergencies.

India has Its Own Warning Signs

India is not among the countries driving WHO’s current global conflict tally, but the protection of health care is not an abstract issue here. In Manipur, where intercommunal violence began in May 2023, the Safeguarding Health in Conflict Coalition documented eight incidents of violence against or obstruction of health care in 2024. Health facilities were attacked on five occasions. The incidents included a grenade delivered to a hospital and a bomb thrown at a medical university campus. Routine immunisation, maternal health services and treatment for chronic diseases were disrupted.

The Manipur case shows why attacks on health care matter even when the number of incidents is relatively small compared with the world’s largest conflicts. A single attack can affect an entire catchment area when alternative facilities are limited.

Research from Assam provides another perspective. A study of ASHA workers in conflict-affected districts found that they faced difficulties arranging transport and accessing remote health facilities during and after episodes of violence. Their physical safety was also at risk, while displacement and the breakdown of social relationships created additional pressures on their work.

These community health workers are particularly important because they connect people in remote communities with the formal health system. When conflict prevents them from travelling safely, the disruption reaches households far beyond the site of the violence.

Violence in Indian Hospitals is a Different, But Related, Problem

There is an important distinction between attacks on health care in armed conflict and violence against health workers in ordinary health-care settings. They should not be treated as the same phenomenon. India, however, has a significant problem with workplace violence against medical professionals.

A 2026 study published in the National Medical Journal of India, based on 439 doctors’ responses, found that 80.2% had faced or witnessed workplace violence. Verbal abuse was the most common form, followed by physical and sexual violence. Respondents reported effects on their mental health that could last from weeks to a year. Another study involving emergency-department health-care providers in two Indian settings found that 68% reported verbal abuse and 26% physical abuse among the events examined. Patient relatives and other bystanders were reported as the most common perpetrators.

India responded during the COVID-19 pandemic by amending the Epidemic Diseases Act in 2020. The amendment made violence against health-care personnel during an epidemic a cognizable and non-bailable offence, with penalties that can include imprisonment and fines.

But the persistence of violence suggests that legal protection alone does not guarantee safety.

Protection is Part of Health Care

International humanitarian law already provides protections for medical personnel, facilities and transport during armed conflict. UN Security Council Resolution 2286, adopted in 2016, specifically condemned attacks against medical facilities and personnel and called for stronger compliance with international humanitarian law.

A decade later, the problem remains. The Safeguarding Health in Conflict Coalition’s latest assessment argues that the consequences extend to millions of people who lose access to health care when facilities and workers are attacked. It has called for stronger accountability mechanisms and greater political action to enforce existing protections.

The central issue, therefore, is not simply how many doctors, nurses or patients are killed. It is what happens to everyone who needs care after the health system around them has been damaged. When a hospital becomes a conflict zone, it is a maternity ward that cannot admit a woman, a clinic unable to vaccinate a child, an ambulance that cannot reach an injured person, or a doctor who decides it is no longer safe to stay. Protecting health care is ultimately about protecting the ability of people to receive care when they need it most.

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Kerala Doctors Find Glass Fragments Lodged in Woman’s Spine, 12 Years After Accident

Doctors in Kochi removed three glass fragments lodged near a woman’s spine for 12 years after 3D CT imaging finally revealed the cause of her chronic back pain.

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Kochi Doctors Find Glass Fragments Lodged in Woman's Spine
The image shows three glass fragments removed after 12 years, alongside CT and 3D reconstruction scans identifying their location near the woman's spine. Image credit: By special arrangement

Kochi, Kerala: A 44-year-old woman from Karunagappally in Kollam has undergone surgery to remove three glass fragments that had remained lodged near her spine for 12 years, after imaging finally identified the source of pain that doctors had previously been unable to explain.

Manu S B had lived with chronic back pain since 2014, when she fell onto a glass-topped table while eight months pregnant and attending a family wedding. Glass shattered on impact and pierced her back. She was treated at a hospital at the time, but not all the fragments could be located, and some remained embedded in the tissue near her spine.

Over the following twelve years, Manu consulted multiple hospitals without a diagnosis. Her husband, Rajeeve, said the unexplained pain affected her sleep, her ability to raise her arms, and eventually her work as a Taluk Supply Officer in Karunagappally. Family members said the prolonged, undiagnosed pain also took a psychological toll, with some around her suggesting the problem was not physical.

A recent consultation led doctors to suspect a tumour-like lesion and recommend an MRI. Rajeeve then approached Dr Krishnakumar R, Director of the Institute of Spine and Scoliosis Surgery at VPS Lakeshore Hospital, under whom he had previously undergone surgery. A subsequent 3D CT scan identified the retained glass fragments, including one triangular piece measuring roughly 3 cm.

Surgeons removed the three fragments from the mid-back region of Manu’s spine last week, in a procedure led by Dr Krishnakumar with support from the hospital’s radiology and anaesthesiology teams. She is currently recovering at VPS Lakeshore Hospital.

“Pain that continues for years after an injury needs careful evaluation,” Dr Krishnakumar said. “In this case, imaging helped us identify the retained glass fragments and understand the reason for her longstanding symptoms.”

Rajeeve said much of the earlier medical attention over the years had focused on Manu’s neck rather than the back, which he believes contributed to the delay in diagnosis.

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AI Finds the Hidden Cells That May Help Cancer Return

Indian researchers have developed an AI framework, ACSCeND, that identifies hidden cancer stem-like cell states from tumour gene-expression data. Analysis of more than 25,000 tumour samples linked highly potent cells with poorer survival, cancer recurrence and reduced response to immunotherapy.

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Cancer research laboratory setup with test tubes, syringes and a pink cancer awareness ribbon
Laboratory imagery representing research into hidden cancer stem cells linked to tumour recurrence and treatment resistance. Representational image. Image credit: Tara Winstead/Pexels

India recorded an estimated 15.6 lakh new cancer cases and 8.74 lakh cancer deaths in 2024, according to estimates based on data from 43 cancer registries. Cancer is now the second leading cause of death globally after cardiovascular diseases, with the World Health Organization estimating 20.6 million new cases and nearly 10 million deaths worldwide in 2024. Against this growing burden, cancer stem cells are emerging as a critical target in understanding why tumours return and resist treatment.

The growing cancer burden has made early detection, effective treatment and preventing recurrence critical challenges. While advances in surgery, chemotherapy, radiation, targeted therapies and immunotherapy have improved treatment options, cancer can still return after an apparently successful treatment. One reason may lie in a small population of cancer stem cells that can remain hidden inside a tumour.

These are known as cancer stem cells. Although they make up only a small fraction of a tumour, researchers believe they can play an important role in tumour recurrence, metastasis and treatment resistance. Their rarity and ability to change their identity have also made them difficult to detect. This is where a new Indian research effort could offer a different way of looking at cancer.

Researchers from the S. N. Bose National Centre for Basic Sciences, an autonomous institute under the Department of Science and Technology, in collaboration with Ashoka University, have developed an artificial intelligence framework that can identify hidden cancer stem-like cell populations from tumour gene-expression data.

Called ACSCeND, or AI-based Cancer Stem Cells Profiler and Neoplasm Deconvoluter, the framework could help researchers examine cancer biology at a level that conventional tumour analysis may miss.

Cancer Stem Cells: Understanding Single Stemness Score

Cancer is not a uniform mass of identical cells. Different cells within the same tumour can behave differently, with some populations potentially more capable of surviving treatment and driving tumour growth.

Conventional computational approaches often assign a tumour a single “stemness” score. ACSCeND instead identifies three distinct developmental states of cancer stem-like cells: pluripotent-like, multipotent-like and unipotent-like.

The distinction could give researchers a more detailed picture of the biological composition of a tumour.

Cancer stem cells
Microscopic view illustrating cellular structures, contextualising research into hidden cancer stem-like cells associated with tumour recurrence and treatment resistance. Representational image. Image credit: Fayette Reynolds M.S./Pexels

The framework combines information learned from high-resolution single-cell sequencing with deep learning to analyse conventional bulk tumour RNA sequencing. This is significant because single-cell experiments are not available for every tumour sample, while large collections of conventional RNA sequencing data already exist.

In effect, the researchers are using AI to extract information about hidden cell populations from data that may otherwise appear less detailed.

Tested Across More Than 25,000 Tumours

The researchers validated ACSCeND against existing computational methods and tested it across independent datasets and sequencing platforms. They then applied the framework to more than 25,000 tumour samples from major international cancer databases, including TCGA and PRECOG.

The analysis revealed a significant association between the presence of highly potent, pluripotent-like cancer stem cells and poorer outcomes. Tumours enriched with these cancer stem cells were associated with poorer patient survival, a greater likelihood of recurrence and reduced response to modern immunotherapies.

The framework also identified molecular programmes that may help these cells survive, adapt and evade the immune system. Such findings could provide researchers with potential targets for future drug development and help identify patients who may be more likely to relapse.

Why This Could Matter for Precision Medicine

The significance of the research lies not in AI replacing cancer doctors or predicting an individual patient’s future, but in its ability to reveal biological patterns that are difficult to detect using conventional analysis.

If researchers can better identify the cell populations that are associated with recurrence and treatment resistance, they may gain a clearer understanding of why some tumours return after apparently successful treatment. That knowledge could eventually contribute to therapies designed to target not only the bulk of a tumour but also the populations of cells that help it survive.

The approach could also be valuable because it works with conventional bulk RNA sequencing data. Instead of requiring every tumour sample to undergo expensive and highly detailed single-cell analysis, researchers may be able to investigate hidden cancer stem-like populations across much larger collections of existing samples.

For India, where an estimated 15.6 lakh people were diagnosed with cancer in 2024, such computational approaches could strengthen cancer research and the country’s move towards more data-driven precision medicine.

But the findings need to be viewed in context. ACSCeND is currently a research framework, not a clinical diagnostic tool that can determine whether an individual patient’s cancer will return. The study establishes associations between cancer stem cells states and outcomes; translating those findings into clinical decisions will require further research and validation.

The potential turning point, therefore, is not that AI has solved cancer recurrence. It is that researchers now have another way to look for the cancer stem cells that may be helping tumours survive treatment.

In the long battle against cancer, understanding what remains after treatment may be just as important as understanding what the treatment destroys.

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