The Sciences
Giant Human Antibody Found to Act Like a Brace Against Bacterial Toxins
This synergistic bracing action gives IgM a unique advantage in neutralizing bacterial toxins that are exposed to mechanical forces inside the body
Our immune system’s largest antibody, IgM, has revealed a hidden superpower — it doesn’t just latch onto harmful microbes, it can also act like a brace, mechanically stabilizing bacterial toxins and stopping them from wreaking havoc inside our bodies.
A team of scientists from the S.N. Bose National Centre for Basic Sciences (SNBNCBS) in Kolkata, India, an autonomous institute under the Department of Science and Technology (DST), made this discovery in a recent study. The team reports that IgM can mechanically stiffen bacterial proteins, preventing them from unfolding or losing shape under physical stress.
“This changes the way we think about antibodies,” the researchers said in a media statement. “Traditionally, antibodies are seen as chemical keys that unlock and disable pathogens. But we show they can also serve as mechanical engineers, altering the physical properties of proteins to protect human cells.”
Unlocking a new antibody role
Our immune system produces many different antibodies, each with a distinct function. IgM, the largest and one of the very first antibodies generated when our body detects an infection, has long been recognized for its front-line defense role. But until now, little was known about its ability to physically stabilize dangerous bacterial proteins.
The SNBNCBS study focused on Protein L, a molecule produced by Finegoldia magna. This bacterium is generally harmless but can become pathogenic in certain situations. Protein L acts as a “superantigen,” binding to parts of antibodies in unusual ways and interfering with immune responses.

Using single-molecule force spectroscopy — a high-precision method that applies minuscule forces to individual molecules — the researchers discovered that when IgM binds Protein L, the bacterial protein becomes more resistant to mechanical stress. In effect, IgM braces the molecule, preventing it from unfolding under physiological forces, such as those exerted by blood flow or immune cell pressure.
Why size matters
The stabilizing effect depended on IgM concentration: more IgM meant stronger resistance. Simulations showed that this is because IgM’s large structure carries multiple binding sites, allowing it to clamp onto Protein L at several locations simultaneously. Smaller antibodies lack this kind of stabilizing network.
“This synergistic bracing action gives IgM a unique advantage in neutralizing bacterial toxins that are exposed to mechanical forces inside the body,” the researchers explained.
The finding highlights an overlooked dimension of how our immune system works — antibodies don’t merely bind chemically but can also act as mechanical modulators, physically disarming toxins.
Such insights could open a new frontier in drug development, where future therapies may involve engineering antibodies to stiffen harmful proteins, effectively locking them in a harmless state.
The study suggests that by harnessing this natural bracing mechanism, scientists may be able to design innovative treatments that go beyond traditional antibody functions.
The Sciences
Researchers crack greener way to mine lithium, cobalt and nickel from dead batteries
A breakthrough recycling method developed at Monash University in Australia can recover over 95% of critical metals from spent lithium-ion batteries—without extreme heat or toxic chemicals—offering a major boost to clean energy and circular economy goals.
Researchers at Monash University, based in Melbourne, Australia, have developed a breakthrough, environmentally friendly method to recover high-purity nickel, cobalt, manganese and lithium from spent lithium-ion batteries, offering a safer alternative to conventional recycling processes.
The new approach uses a mild and sustainable solvent, avoiding the high temperatures and hazardous chemicals typically associated with battery recycling. The innovation comes at a critical time, as an estimated 500,000 tonnes of spent lithium-ion batteries have already accumulated globally. Despite their growing volume, recycling rates remain low, with only around 10 per cent of spent batteries fully recycled in countries such as Australia.
Most discarded batteries end up in landfills, where toxic substances can seep into soil and groundwater, gradually entering the food chain and posing long-term health and environmental risks. This is particularly concerning given that spent lithium-ion batteries are rich secondary resources, containing strategic metals including lithium, cobalt, nickel, manganese, copper, aluminium and graphite.
Existing recovery methods often extract only a limited range of elements and rely on energy-intensive or chemically aggressive processes. The Monash team’s solution addresses these limitations by combining a novel deep eutectic solvent (DES) with an integrated chemical and electrochemical leaching process.
Dr Parama Banerjee, principal supervisor and project lead from the Department of Chemical and Biological Engineering, said the new method achieves more than 95 per cent recovery of nickel, cobalt, manganese and lithium, even from industrial-grade “black mass” that contains mixed battery chemistries and common impurities.

“This is the first report of selective recovery of high-purity Ni, Co, Mn, and Li from spent battery waste using a mild solvent,” Dr Banerjee said.
“Our process not only provides a safer, greener alternative for recycling lithium-ion batteries but also opens pathways to recover valuable metals from other electronic wastes and mine tailings.”
Parisa Biniaz, PhD student and co-author of the study, said the breakthrough represents a significant step towards a circular economy for critical metals while reducing the environmental footprint of battery disposal.
“Our integrated process allows high selectivity and recovery even from complex, mixed battery black mass. The research demonstrates a promising approach for industrial-scale recycling, recovering critical metals efficiently while minimising environmental harm,” Biniaz said.
The researchers say the method could play a key role in supporting sustainable energy transitions by securing critical mineral supplies while cutting down on environmental damage from waste batteries.
Sustainable Energy
Can ammonia power a low-carbon future? New MIT study maps global costs and emissions
Under what conditions can ammonia truly become a low-carbon energy solution? MIT researchers attempt to resolve this
Ammonia, long known as the backbone of global fertiliser production, is increasingly being examined as a potential pillar of the clean energy transition. Energy-dense, carbon-free at the point of use, and already traded globally at scale, ammonia is emerging as a candidate fuel and a carrier of hydrogen. But its climate promise comes with a contradiction: today’s dominant method of producing ammonia carries a heavy carbon footprint.
A new study by researchers from the MIT Energy Initiative (MITEI) attempts to resolve this tension by answering a foundational question for policymakers and industry alike: under what conditions can ammonia truly become a low-carbon energy solution?
A global view of ammonia’s future
In a paper published in Energy and Environmental Science, the researchers present the largest harmonised dataset to date on the economic and environmental impacts of global ammonia supply chains. The analysis spans 63 countries and evaluates multiple production pathways, trade routes, and energy inputs, offering a comprehensive view of how ammonia could be produced, shipped, and used in a decarbonising world.
“This is the most comprehensive work on the global ammonia landscape,” says senior author Guiyan Zang, a research scientist at MITEI. “We developed many of these frameworks at MIT to be able to make better cost-benefit analyses. Hydrogen and ammonia are the only two types of fuel with no carbon at scale. If we want to use fuel to generate power and heat, but not release carbon, hydrogen and ammonia are the only options, and ammonia is easier to transport and lower-cost.”
Why data matters
Until now, assessments of ammonia’s climate potential have been fragmented. Individual studies often focused on single regions, isolated technologies, or only cost or emissions, making global comparisons difficult.
“Before this, there were no harmonized datasets quantifying the impacts of this transition,” says lead author Woojae Shin, a postdoctoral researcher at MITEI. “Everyone is talking about ammonia as a super important hydrogen carrier in the future, and also ammonia can be directly used in power generation or fertilizer and other industrial uses. But we needed this dataset. It’s filling a major knowledge gap.”
To build the database, the team synthesised results from dozens of prior studies and applied common frameworks to calculate full lifecycle emissions and costs. These calculations included feedstock extraction, production, storage, shipping, and import processing, alongside country-specific factors such as electricity prices, natural gas costs, financing conditions, and energy mix.
Comparing production pathways
Today, most ammonia is produced using the Haber–Bosch process powered by fossil fuels, commonly referred to as “grey ammonia.” In 2020, this process accounted for about 1.8 percent of global greenhouse gas emissions. While economically attractive, it is also the most carbon-intensive option.
The study finds that conventional grey ammonia produced via steam methane reforming (SMR) remains the cheapest option in the U.S. context, at around 48 cents per kilogram. However, it also carries the highest emissions, at 2.46 kilograms of CO₂ equivalent per kilogram of ammonia.
Cleaner alternatives offer substantial emissions reductions at higher cost. Pairing SMR with carbon capture and storage cuts emissions by about 61 percent, with a 29 percent cost increase. A full global shift to ammonia produced with conventional methods plus carbon capture could reduce global greenhouse gas emissions by nearly 71 percent, while raising costs by 23.2 percent.
More advanced “blue ammonia” pathways, such as auto-thermal reforming (ATR) with carbon capture, deliver deeper emissions cuts at relatively modest cost increases. One ATR configuration achieved emissions of 0.75 kilograms of CO₂ equivalent per kilogram of ammonia, at roughly 10 percent higher cost than conventional SMR.
At the far end of the spectrum, “green ammonia” produced using renewable electricity can reduce emissions by as much as 99.7 percent, but at a significantly higher cost—around 46 percent more than today’s baseline. Ammonia produced using nuclear electricity showed near-zero emissions in the analysis.
Geography matters
The study also reveals that the viability of low-carbon ammonia depends heavily on geography. Countries with abundant, low-cost natural gas are better positioned to produce blue ammonia competitively, while regions with cheap renewable electricity are more favourable for green ammonia.
China emerged as a potential future supplier of green ammonia to multiple regions, while parts of the Middle East showed strong competitiveness in low-carbon ammonia production. In contrast, ammonia produced using carbon-intensive grid electricity was often both more expensive and more polluting than conventional methods.
From research to policy
Interest in low-carbon ammonia is no longer theoretical. Countries such as Japan and South Korea have incorporated ammonia into national energy strategies, including pilot projects using ammonia for power generation and financial incentives tied to verified emissions reductions.
“Ammonia researchers, producers, as well as government officials require this data to understand the impact of different technologies and global supply corridors,” Shin says.
Zang adds that the dataset is designed not just as an academic exercise, but as a decision-making tool. “We collaborate with companies, and they need to know the full costs and lifecycle emissions associated with different options. Governments can also use this to compare options and set future policies. Any country producing ammonia needs to know which countries they can deliver to economically.”
As global demand for low-carbon fuels accelerates toward mid-century, the study suggests that ammonia’s role will depend less on ambition alone, and more on informed choices—grounded in data—about how and where it is produced.
The Sciences
Why Octopuses Have Three Hearts, And Why Their Bodies Are Stranger Than Fiction
And the reason is surprisingly practical
Octopuses are already odd enough — eight arms, no bones, a brain that wraps around their throat — but one detail still stops people in their tracks: they have three hearts. Not two. Not one. Three.
And the reason is surprisingly practical.
Three Hearts for a Tough Life Underwater
Two of the hearts — called branchial hearts — do a very specific job: each one pushes blood through a gill, where it can pick up oxygen. The third, the systemic heart, takes that oxygen-rich blood and pumps it to the rest of the body.
In other words: two hearts to breathe, one heart to live.
Why Their Blood Is Blue
Another strange thing: their blood isn’t red at all.
It’s blue — literally blue — because it’s based on copper, not iron.
The copper-based protein, hemocyanin, works better in the cold, low-oxygen parts of the ocean where many octopuses live. It keeps them alive in places where most animals wouldn’t last a minute. But it’s not very efficient, so their bodies need extra pumping power to keep the oxygen flowing.
Evolution’s answer? Give them more hearts.
A Heart That Stops When They Swim
Here’s the part that sounds almost fictional: when an octopus swims, its main heart actually stops.
Imagine going for a swim and your heart taking a break halfway through. That’s why octopuses prefer to crawl on the seafloor. Swimming is simply too tiring — it literally costs them heartbeats.
The Ocean’s Quiet Genius
When you combine all of this — the blue blood, the three hearts, the bizarre nervous system, the ability to vanish into their surroundings — you get one of the most unusual and surprisingly intelligent creatures on the planet.
Octopuses don’t just survive in harsh oceans; they’ve evolved in ways that feel almost alien. And maybe that’s why we’re endlessly fascinated by them — they remind us how strange and creative life can be.
-
Society4 weeks agoThe Ten-Rupee Doctor Who Sparked a Health Revolution in Kerala’s Tribal Highlands
-
COP303 months agoBrazil Cuts Emissions by 17% in 2024—Biggest Drop in 16 Years, Yet Paris Target Out of Reach
-
Earth3 months agoData Becomes the New Oil: IEA Says AI Boom Driving Global Power Demand
-
COP303 months agoCorporate Capture: Fossil Fuel Lobbyists at COP30 Hit Record High, Outnumbering Delegates from Climate-Vulnerable Nations
-
Society1 month agoFrom Qubits to Folk Puppetry: India’s Biggest Quantum Science Communication Conclave Wraps Up in Ahmedabad
-
Space & Physics2 months agoIndian Physicists Win 2025 ICTP Prize for Breakthroughs in Quantum Many-Body Physics
-
Women In Science4 months agoThe Data Don’t Lie: Women Are Still Missing from Science — But Why?
-
Health3 months agoAir Pollution Claimed 1.7 Million Indian Lives and 9.5% of GDP, Finds The Lancet


