Health
Study Reveals Essential Genes That Help Tuberculosis Survive Airborne Transmission
Tuberculosis is a respiratory disease caused by Mycobacterium tuberculosis, a bacterium that predominantly affects the lungs and spreads through droplets released by an infected person
Tuberculosis thrives in the lungs, but when the bacteria causing the disease are expelled into the air, they face a much harsher environment with drastic changes in pH and chemistry. Understanding how these bacteria survive this airborne journey is essential for their persistence, yet little is known about the mechanisms that protect them as they move from one host to another.
Now, MIT researchers and their collaborators have identified a family of genes that are crucial for the bacterium’s survival specifically when exposed to the air, likely offering protection during its transmission.
Previously, many of these genes were thought to be nonessential, as they didn’t appear to affect the bacteria’s role in causing disease when introduced into a host. This new study, however, suggests that these genes are vital for transmission rather than proliferation.
“There is a blind spot in our understanding of airborne transmission, especially regarding how a pathogen survives sudden environmental changes as it circulates in the air,” says Lydia Bourouiba, head of the Fluid Dynamics of Disease Transmission Laboratory, associate professor of civil and environmental engineering, mechanical engineering, and core faculty member at MIT’s Institute for Medical Engineering and Science. “Now, through these genes, we have an insight into the tools tuberculosis uses to protect itself.”
The team’s findings, published this week in Proceedings of the National Academy of Sciences, could lead to new tuberculosis therapies that target both infection and transmission prevention.
“If a drug targeted the products of these genes, it could effectively treat an individual and, even before that person is cured, prevent the infection from spreading,” says Carl Nathan, chair of the Department of Microbiology and Immunology and the R.A. Rees Pritchett Professor of Microbiology at Weill Cornell Medicine.
Nathan and Bourouiba co-senior authored the study, which includes MIT collaborators and Bourouiba’s mentees from the Fluids and Health Network: co-lead author postdoc Xiaoyi Hu, postdoc Eric Shen, and students Robin Jahn and Luc Geurts. The research also involved collaborators from Weill Cornell Medicine, the University of California at San Diego, Rockefeller University, Hackensack Meridian Health, and the University of Washington.
Pathogen’s Perspective
Tuberculosis is a respiratory disease caused by Mycobacterium tuberculosis, a bacterium that predominantly affects the lungs and spreads through droplets released by an infected person, typically when they cough or sneeze. Tuberculosis remains the leading cause of death from infection, except during global viral pandemics.
“In the last century, we’ve seen the 1918 influenza pandemic, the 1981 HIV/AIDS epidemic, and the 2019 SARS-CoV-2 pandemic,” notes Nathan. “Each virus has caused significant loss of life, but after they subsided, we were left with the ‘permanent pandemic’ of tuberculosis.”
Much of the research on tuberculosis focuses on its pathophysiology—how the bacteria infect a host—along with diagnostic and treatment methods. For their new study, Nathan and Bourouiba turned their attention to tuberculosis transmission, specifically exploring how the bacteria defend themselves during airborne transmission.
“This is one of the first efforts to study tuberculosis from an airborne perspective, investigating how the organism survives harsh changes in the environment during transmission,” says Bourouiba.
Critical Defense
At MIT, Bourouiba studies fluid dynamics and how droplet behaviors can spread particles and pathogens. She partnered with Nathan, who investigates tuberculosis and the genes that the bacteria rely on throughout their life cycle.
To explore how tuberculosis survives in the air, the team aimed to replicate the conditions the bacterium encounters during transmission. They first worked to develop a fluid with similar viscosity and droplet sizes to those expelled by a person coughing or sneezing. Bourouiba points out that previous research on tuberculosis relied on liquid solutions that are used to grow the bacteria. However, these liquids differ significantly from the fluids tuberculosis patients expel.
Furthermore, the fluid typically sampled from tuberculosis patients, like sputum for diagnostic tests, is thick and sticky, which makes it inefficient at spreading and forming inhalable droplets. “It’s too gooey to break into inhalable droplets,” Bourouiba explains.
Through her research on fluid and droplet physics, the team determined a more accurate viscosity and droplet size distribution for tuberculosis-laden microdroplets in the air. They also analyzed the composition of droplets by studying infected lung tissue samples. They then created a fluid that mimicked the viscosity, surface tension, and droplet size that would be released into the air when a person exhales.
Next, the team deposited different fluid mixtures onto plates as tiny droplets, measuring how they evaporated and what structures they left behind. They discovered that the new fluid shielded the bacteria at the center of the droplet, unlike traditional fluids where bacteria were more exposed to the air. The realistic fluid also retained more water.
The team then infused the droplets with bacteria carrying genes with various knockdowns to see how the absence of specific genes affected bacterial survival during evaporation.
They evaluated over 4,000 tuberculosis genes and identified a family of genes that became crucial in airborne conditions. Many of these genes are involved in repairing damage to oxidized proteins, such as those exposed to air, while others are responsible for breaking down irreparably damaged proteins.
“What we found is a lengthy list of candidate genes, some more prominently involved than others, that could play a critical role in helping tuberculosis survive during transmission,” Nathan says.
While the experiments cannot fully replicate the bacteria’s biophysical transmission (as droplets fly through the air and evaporate), the team mimicked these conditions by placing plates in a dry chamber to accelerate droplet evaporation, similar to what happens in flight.
Going forward, the researchers are developing platforms to study droplets in flight under various conditions. They plan to further investigate the role of the newly identified genes in more realistic experiments, potentially weakening tuberculosis’s airborne defenses.
“The idea of waiting to diagnose and treat someone with tuberculosis is an inefficient way to stop the pandemic,” Nathan says. “Most individuals who exhale tuberculosis haven’t been diagnosed yet, so we need to interrupt its transmission. Understanding the process is key, and now we have some ideas.”
Health
Why Planetary Health Is Failing —and How Smarter Communication Can Save It
Why Planetary Health Is Failing —and How Smarter Communication Can Save It
A major report, Voices for Planetary Health: Leveraging AI, Media and Stakeholder Strengths for Effective Narratives to Advance Planetary Health, produced by the Sunway Centre for Planetary Health at Sunway University and implemented by Internews, offers the first systematic mapping of how planetary health issues are communicated across the world. Its conclusion is clear: ineffective, fragmented communication is undermining humanity’s ability to respond to accelerating environmental and health crises. A Fractured Narrative The research team analysed 96 organizations and individuals across nine countries through interviews and social media mapping. What they found was striking. Despite decades of science showing the deep interconnections between climate change, pollution, biodiversity loss, and human health, global communication remains disjointed, inconsistent, and highly vulnerable to misinformation.
“We know the science. What we lack is a shared story that resonates across communities, cultures, and decision makers,” said Prof. Dr. Jemilah Mahmood, Executive Director of the Sunway Centre for Planetary Health. Most communication efforts are siloed—environment separate from health, climate from social justice, science from lived experience. The report notes that short-term projects, scarce resources, and discipline-bound narratives prevent the creation of powerful, sustained public messages capable of shifting policy or behaviour. AI: Powerful and Dangerous One of the study’s most urgent insights concerns artificial intelligence.
AI can dramatically expand communication capacity through multilingual translation, rapid content generation, and greater accessibility. But it also creates new risks that threaten planetary health messaging. Generative AI tools can be weaponized to fabricate climate falsehoods—from bot-driven denialist content to deepfake campaigns undermining activists. AI systems also reflect structural bias; research cited in the report shows that many models privilege Western epistemologies while marginalizing Indigenous and local knowledge, contributing to what scholars term “global conservation injustices.”

And AI’s own environmental footprint cannot be ignored. Data centres already consume about 1.5 percent of global electricity, with AI-specialized facilities drawing power comparable to aluminium smelters. Training advanced models such as GPT-4 requires three to five times more energy than GPT-3—an escalation that amplifies the very planetary pressures the field is trying to solve.
Communities Most at Risk Are the Least Heard The communication gap most severely harms those already disproportionately burdened by climate-related health threats. The report highlights how marginalized communities—including low-income groups, Indigenous peoples, and communities of colour—face higher exposure to extreme heat, flooding, respiratory illnesses, vector-borne diseases, and pollution-driven health impacts.
These same communities often lack access to reliable planetary health information. Complex scientific jargon, limited translation, and English-dependent messaging create substantial barriers, leaving many without the knowledge needed to advocate for or protect themselves.Multiple studies confirm that racially and socioeconomically marginalized communities in the United States experience greater impacts from climate related health events, including extreme heat, flooding, and respiratory illnesses. Children of colour are particularly vulnerable, experiencing disproportionate health impacts from climate exposures compared to white children. The communication barriers compound these vulnerabilities.

Scientific jargon makes planetary health concepts inaccessible to general audiences, while language delivery challenges—including complex English or lack of translation—further limit reach to non-English speaking communities. Yet young people emerge as a rare bright spot. The study finds that youth activists are using digital platforms— especially Instagram, TikTok, and community networks— to push for environmental accountability. But they still confront algorithmic bias, inconsistent platform moderation, and limited institutional support.
A Blueprint for Coherent, Inclusive Communication
To fix the communication failure, the report proposes a dual framework: strategic communication aimed at policy, and democratic communication rooted in community level dialogue. It outlines six guiding principles: centering marginalized voices; treating planetary health as one integrated story; connecting disciplines and geographies; anticipating backlash and protecting communicators; adapting messages to cultural context; and working with people’s existing mental models. “Communication is not just a tool; it is a catalyst for change.
By speaking with courage, coherence, and compassion, and equipping all actors to tell inclusive stories, we can turn knowledge into action and ensure no voice is left behind,” said Jayalakshmi Shreedhar of Internews. As political rollbacks weaken environmental safeguards and six of nine planetary boundaries are already breached, the stakes could not be higher. Science alone will not save us. A compelling, coherent planetary health narrative—shared across societies—just might
Climate
The World Warms, Extreme Heat Becomes the New Normal
As global temperatures continue to rise, extreme heat is no longer a distant threat. It is a present and growing challenge that will shape health, livelihoods, and living conditions for billions of people unless decisive action is taken.
A new study from the University of Oxford has issued a stark warning about the future of global temperatures, finding that nearly half of the world’s population could be living under conditions of extreme heat by 2050. If global warming reaches 2°C above pre-industrial levels—a scenario climate scientists see as increasingly likely—around 3.79 billion people could experience dangerously high temperatures, reshaping daily life across the planet.
The findings, published in Nature Sustainability, suggest that the impacts of rising temperatures will be felt much sooner than expected. In 2010, approximately 23% of the global population lived with extreme heat; this figure is projected to rise to 41% in the coming decades. The study warns that many severe changes will occur even before the world crosses the 1.5°C limit set by the Paris Agreement.
Central African Republic, Nigeria, South Sudan, Laos, and Brazil are expected to see the largest increases in dangerously hot temperatures
According to the study, countries such as the Central African Republic, Nigeria, South Sudan, Laos, and Brazil are expected to see the largest increases in dangerously hot temperatures. Meanwhile, some of the world’s most populous nations—including India, Nigeria, Indonesia, Bangladesh, Pakistan, and the Philippines—will have the highest numbers of people exposed to extreme heat.
The research also shows that colder countries such as the United Kingdom, Canada, Sweden, Finland, Norway, and Ireland could experience relatively dramatic increases in the number of hot days. Compared with the 2006–2016 period, warming to 2°C could lead to a 150% increase in extreme heat days in the UK and Finland, and more than a 200% increase in countries such as Norway and Ireland.
This raises concerns because infrastructure in colder regions is largely designed to retain heat rather than release it. Buildings that maximise insulation and solar gain may become uncomfortable—or even unsafe—during hotter periods, placing additional strain on energy systems and public health services.
Dr Jesus Lizana, lead author of the study and Associate Professor of Engineering Science at the University of Oxford, said the most critical changes will occur sooner than many expect. “Our study shows most of the changes in cooling and heating demand occur before reaching the 1.5°C threshold, which will require significant adaptation measures to be implemented early on,” he said. He added that many homes may need air conditioning within the next five years, even though temperatures will continue to rise if global warming reaches 2°C.
Dr Lizana also emphasised the need to address climate change without increasing emissions. “To achieve the global goal of net-zero carbon emissions by 2050, we must decarbonise the building sector while developing more effective and resilient adaptation strategies,” he noted.
Dr Radhika Khosla, Associate Professor at Oxford’s Smith School of Enterprise and the Environment and leader of the Oxford Martin Future of Cooling Programme, described the findings as a wake-up call. “Overshooting 1.5°C of warming will have an unprecedented impact on everything from education and health to migration and farming,” she said, adding that sustainable development and renewed political commitment to net-zero emissions remain the most established pathway to reversing the trend of ever-hotter days.
Rising temperatures will have far-reaching impacts beyond discomfort. Demand for cooling systems is expected to rise sharply, particularly in regions that already struggle with access to electricity. At the same time, demand for heating may decline in colder countries, leading to uneven shifts in global energy use.
Dr Luke Parsons, a senior scientist at The Nature Conservancy, said the study adds to evidence that heat exposure in vulnerable communities is accelerating faster than previously predicted. He noted that communities least responsible for climate change often face the harshest impacts, underscoring the environmental justice dimensions of the crisis. Addressing the challenge, he said, will require urgent action on both mitigation and adaptation, including rapid emissions reductions and the expansion of equitable cooling solutions.
As global temperatures continue to rise, extreme heat is no longer a distant threat. It is a present and growing challenge that will shape health, livelihoods, and living conditions for billions of people unless decisive action is taken.
COP30
Health Systems ‘Unprepared’ as Climate Impacts Intensify, Experts Warn at COP30
India will require $643 billion between now and 2030 to adapt to climate change under a business-as-usual scenario
On Health Day at COP30 (November 13), global health and climate experts warned that the world is dangerously underprepared for the accelerating health impacts of climate change, calling for a dramatic scale-up of adaptation finance to protect vulnerable populations.
Speaking at a press conference hosted by Regions4, the Global Climate & Health Alliance and CarbonCopy, leaders from research institutions and national governments said climate-linked health threats — from extreme heat to wildfire smoke — are rising sharply while funding remains “colossally” insufficient.
“Each year, more than half a million lives are lost due to heat, and over 150,000 deaths are linked to wildfire smoke exposure,” said Dr. Marina Romanello, Executive Director of the Lancet Countdown. “Health systems, already stretched and underfunded, are struggling to cope with these growing pressures, and most are still unprepared for what is coming.”
Romanello added that despite the scale of the crisis, “only 44% of countries have costed their health adaptation needs, and existing finance falls short by billions. Without urgent investment, we will not be able to protect populations from escalating climate impacts.”
Adaptation gap continues to widen
The speakers described health-sector underfunding as a critical part of the broader adaptation finance gap. The latest UNEP Adaptation Gap Report estimates developing countries will need $310–365 billion annually by 2035, while the international community is still struggling to mobilise even the $40 billion Glasgow Pact Goal.
“With regards to finance, the reality is that we have a deficit that is quite colossal,” said Carlos Lopes, Special Envoy for Africa, COP30 Presidency. “Most of the efforts are from national authorities. What we need from international finance is that it must be complementary.”
Lopes cautioned that climate and health policy still operates in “multiple contested layers,” warning that unless these are aligned, “we risk losing coherence in our global response.”
Countries highlight urgent needs
Representatives from Bangladesh, Nigeria, India and Chile echoed concerns that adaptation finance is far from matching on-ground needs.
“Our adaptation financing for health is far below what is needed. The gap between what we require and what we receive is enormous,” said Md Ziaul Haque, Additional Director General, Ministry of Environment, Bangladesh. He urged multilateral finance entities to bring forward “concrete, holistic proposals that match the scale of the challenge.”
Nigeria’s challenges are equally stark. “In Nigeria, we are facing an additional 21% disease burden due to climate change… yet the adaptation finance we received in 2021–22 only met 6% of our needs,” said Oden Ewa, Commissioner for Special Duties and Green Economy Lead. He called adaptation finance a “lifeline that saves lives, strengthens communities, and protects economies.”
India outlines its adaptation burden
India also presented updated estimates of its climate adaptation needs. “India will require $643 billion between now and 2030 to adapt to climate change under a business-as-usual scenario,” said Dr. Vishwas Chitale of the Council for Energy, Environment & Water. He noted that India has already made “significant progress, spending $146 billion in 2021–2022 alone — 5.6% of GDP.”
New funding coalition signals momentum
Speakers highlighted the launch of the Climate and Health Funders Coalition, which has committed an initial $300 million annually.
“This is an encouraging signal… It shows that the world is beginning to recognise that protecting health must be at the centre of climate adaptation,” said Jeni Miller, Executive Director, Global Climate & Health Alliance.
Health at the centre of adaptation
Chile stressed the need for integrated policy approaches.
“It is vital to combine the efforts of different ministries — not only health but also transport, energy and food production — so that we generate co-benefits across sectors,” said Dr. Sandra Cortes, President of Chile’s Climate Change Scientific Committee. “A more integrated approach will allow us to improve public health, reduce emissions and create fairer, more sustainable development opportunities.”
As negotiators continue discussions in Belém, experts reiterated that adaptation finance — especially for health — must be just, equitable, accessible and prioritise the most climate-vulnerable nations. The recently proposed Belém Health Action Plan and the Global Goal on Adaptation are expected to serve as frameworks for strengthening health system resilience worldwide.
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