In a major development for knee rehabilitation, researchers at Indian Institute of Technology (IIT) Ropar have introduced a revolutionary, low-cost solution to make Continuous Passive Motion (CPM) therapy more accessible to patients. The team’s newly patented innovation, the Completely Mechanical Passive Motion Machine for Knee Rehabilitation, is set to transform post-surgical recovery, especially in resource-limited areas.

Unlike traditional motorized CPM devices, which are expensive and reliant on electricity, the new machine operates entirely through mechanical means. Utilizing a piston and pulley system that stores air as the user pulls a handle, the device enables smooth, controlled knee motion to aid in rehabilitation. This design eliminates the need for electricity, batteries, or motors, making the machine lightweight, portable, and environmentally friendly.

The mechanical CPM machine addresses a key barrier to knee therapy: the high cost and power dependence of conventional electric machines. It offers a viable alternative for patients, particularly in rural and off-grid areas, where access to electricity is often unreliable. Its portability also enables patients to continue their therapy at home, reducing the need for frequent hospital visits or prolonged stays.

Knee rehabilitation is crucial for patients recovering from surgeries, as CPM therapy helps improve joint mobility, reduce stiffness, and speed up recovery. With this new device, IIT Ropar’s researchers are offering a cost-effective, sustainable option that could improve the lives of countless patients, especially in India, where advanced medical technology can be scarce in rural regions.

Lead researcher Dr. Abhishek Tiwari, along with his team members Suraj Bhan Mundotiya and Dr. Samir C. Roy, expressed optimism about the machine’s potential. “This device has the power to revolutionize knee rehabilitation, particularly in areas where access to sophisticated medical equipment is limited. It’s designed to be an affordable and eco-friendly solution that not only aids in recovery but also minimizes environmental impact,” said Dr. Tiwari.

The introduction of this innovative mechanical CPM machine marks a significant step toward democratizing healthcare and improving rehabilitation outcomes globally.

In an enlightening conversation with EdPublica, Sajikumar Sreedharan, Associate Professor at the NUS Yong Loo Lin School of Medicine, Singapore, shares his research insights on memory formation and the transition from short-term to long-term memory. His areas of research include aging and neurodegeneration, the neural basis of long-term memory (LTM), and synaptic tagging and capture (STC) as an elementary mechanism for storing LTM in neural networks. He also explores metaplasticity as a compensatory mechanism for improving memory in neural networks. With a career spanning over two decades, Prof. Sreedharan discusses his key findings, innovative methodologies, and the significance of receiving the “Investigator” award from the International Association for the Study of Neurons and Brain Diseases. Join us as he reflects on his journey and the collaborative spirit that drives his research.

Edited Excerpts:

Your research has been recognized for significantly advancing our understanding of memory formation. Could you elaborate on your key findings related to the transition from short-term to long-term memory?

I have been working in the field of learning and memory since 2000. My first mentor in neuroscience was Prof. T. Ramakrishna, the founder and first head of the Life Sciences Department at the University of Calicut, Kerala, India. He was a great motivator, and we often had insightful discussions about learning and memory in the evenings. I had the chance to work with him for my master’s dissertation, which was my first real research experience. Prof. Ramakrishna encouraged me to expand my knowledge further, and he connected me with Dr. Shobi Valeri, a senior researcher in Delhi at the time.

Dr. Shobi soon left for Germany to pursue his Ph.D. and recommended me to DRDO (Defence Research and Development Organisation). Dr. Shobi is now a senior scientist at the National Institute of Nutrition in Hyderabad. I worked at DRDO for a year before moving to Magdeburg, Germany, where I began my Ph.D. under Prof. Juletta Frey. She is well-known in the field of learning and memory, particularly for her research on the cellular mechanisms involved in forming associative memory.

In Prof. Frey’s lab, I discovered how different pieces of information can link together to form long-term memories. This work later inspired the development of many computational models of memory. After completing my Ph.D., I did my postdoctoral studies with Prof. Martin Korte in Braunschweig. There, I discovered how activating neurons before learning could enhance memory formation in the future, a process known as metaplasticity—an exciting and emerging area of neuroscience.

“Using animal models, we have uncovered the role of specific brain regions, like CA2 and CA1, in forming social and spatial memories—both of which are significantly affected by aging, neurodegenerative diseases, and mental health conditions

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Since 2012, I have been working at the National University of Singapore, where I have focused more on aging, neurodegeneration, and mental health. Using animal models, we have uncovered the role of specific brain regions, like CA2 and CA1, in forming social and spatial memories—both of which are significantly affected by aging, neurodegenerative diseases, and mental health conditions.

How do you approach the study of molecular mechanisms in memory, and what methodologies do you find most effective?

In my lab, we approach research questions by examining them from different angles—molecular, cellular, behavioural, and system-level. We choose the most appropriate method depending on the specific question we’re investigating. I can’t say that one method is better than the others because each plays an important role in confirming our findings.

Recently, we’ve been using optogenetic and chemogenetic tools, which allow us to target and stimulate specific neurons. These methods are particularly helpful because they ensure precision in how we activate or deactivate brain cells.

Congrats on receiving the “Investigator” award from the International Association for the Study of Neurons and Brain Diseases. What does this recognition mean to you personally and professionally?

Thank you for your kind words. As a researcher, I feel proud and happy that my work is being recognized internationally. Professionally, this recognition is a significant motivation to continue pursuing my research.

This achievement is not just mine alone—I owe it to all my Ph.D. students, postdocs, and research technicians who have worked with me over the past 20 years. This award is for them as well.

How do you feel your work contributes to the broader scientific community, especially concerning memory impairments related to aging and mental health?

I am the Research Director of the Healthy Longevity Translational Research Programme at the School of Medicine, National University of Singapore, where we have more than 36 scientists working on various aspects of healthy aging. One of our key areas is brain health. Living a long life is not meaningful without a healthy brain.

I am one of the principal investigators studying how neural networks are impaired during aging and neurodegeneration. My wife, Dr. Sheeja Navakkode, is also a neuroscientist, focusing on Alzheimer’s disease using animal models. Neural networks undergo tremendous changes during aging and in various mental health conditions. Our goal is to correct or rewire neural network activity so that memory can be preserved with minimal damage, especially during conditions such as aging, Alzheimer’s Disease, and mental health disorders.

(Read the full interview in the upcoming December 2024 issue of EdPublica magazine.)

Prof Saleem Badat, a research professor in the Department of History at the University of the Free State (UFS), has been honored with the prestigious Academy of Science of South Africa (ASSAf) Science-for-Society Gold Medal. The award was presented at a gala event in Pretoria, where Prof Badat also announced his intention to donate the accompanying R20,000 prize to the South African BDS Coalition to support Palestinian universities.

Prof Badat, who previously served as Vice-Chancellor of Rhodes University, expressed gratitude for the recognition during his acceptance speech. “Recognition, small or large, is always appreciated. It is a powerful stimulus for reinforcing commitment and invigorating contribution to scholarship and society,” he stated.

Two other UFS academics, Prof Pieter Meintjes and Prof John Carranza, were inaugurated as new ASSAf members at the same event.

The Science-for-Society Gold Medals are awarded to individuals for outstanding achievements in scientific thinking that benefit society. Prof Badat joins the ranks of previous recipients, including prominent figures such as Salim Abdool Karim and Achille Mbembe.

Throughout his career, Prof Badat has focused on issues of equity, social justice, and the decolonization of South African universities. He emphasized the importance of supporting struggling societies, particularly in light of his experiences navigating the oppressive apartheid regime.

In his citation, Prof Vasu Reddy, Deputy Vice-Chancellor at UFS, highlighted Prof Badat’s commitment to social justice and his role as a leader in higher education. “His scholarly understanding combined with anti-apartheid political activism underpin his profound commitment to knowledge and universities,” Reddy noted.

Prof Badat advocates for South African universities to take a leading role in solidarity efforts with Palestinian institutions, calling for greater support for these initiatives from academic communities.

This award not only honours Prof Badat’s significant contributions to scholarship but also highlights the vital connection between academia and social justice, echoing his lifelong dedication to creating equitable and inclusive educational environments.