Health
New Gene Therapy Approach Offers Precision in Treating Genetic Disorders
This innovation could pave the way for safer, more effective gene therapies for conditions like Fragile X syndrome and Friedreich’s ataxia.

Researchers at MIT have made a significant advancement in gene therapy, offering new hope for treating genetic diseases caused by a missing or defective gene. For years, scientists have pursued gene therapy as a potential cure for a range of monogenic diseases, where a single defective gene causes the disorder. However, the challenge has always been controlling how much of the therapeutic gene is expressed in target cells—too little expression means the therapy won’t work, while too much could result in harmful side effects.
In a study published in Cell Systems, MIT engineers have developed a system that delivers precise control over gene expression levels. Their method, called the ComMAND circuit (Compact microRNA-mediated Attenuator of Noise and Dosage), uses a novel feedback mechanism to regulate the amount of gene product produced in cells. This innovation could pave the way for safer, more effective gene therapies for conditions like Fragile X syndrome and Friedreich’s ataxia.
Led by MIT graduate student Kasey Love and senior author Katie Galloway, a professor in biomedical and chemical engineering, the research focuses on a special type of genetic control circuit known as an incoherent feedforward loop (IFFL). The circuit works by simultaneously activating both the target gene and a microRNA that suppresses the gene’s expression. This self-regulation helps keep gene expression at optimal levels—enough to be effective, but not so much as to cause toxicity.
“Gene supplementation can solve many monogenic disorders if we can control the therapy precisely,” explains Galloway. The team demonstrated this technique by targeting genes associated with Fragile X syndrome and Friedreich’s ataxia—both of which result in neurological and developmental issues. They successfully fine-tuned gene expression to levels that were eight times higher than normal, avoiding the excessive expression seen in earlier gene therapies that could have harmful consequences.
The key advantage of the ComMAND circuit is its compact design, which allows it to be delivered using common viral vectors like lentiviruses or adeno-associated viruses—the same delivery systems used in current gene therapy treatments. This simplicity improves the manufacturability and scalability of the therapy.
While the researchers have demonstrated success in human cells, they acknowledge that further tests in animal models are needed to fine-tune the system for clinical use. They hope this technology could eventually benefit patients with a range of genetic disorders, including muscular dystrophy, spinal muscular atrophy, and Rett syndrome.
“Despite the small patient populations for many of these rare diseases, we are working to develop tools that are robust enough for widespread use,” says Galloway, emphasizing the importance of such innovations in addressing diseases that often lack funding and research attention due to their rarity.
The breakthrough is a promising step toward making gene therapy not just a theoretical cure but a reliable, safe treatment option for genetic disorders, with potential applications that could transform the landscape of precision medicine in the years to come.
Health
Researchers Develop Low-Cost Sensor for Real-Time Detection of Toxic Sulfur Dioxide Gas
Sulfur dioxide, a toxic air pollutant primarily released from vehicle exhaust and industrial processes, is notorious for triggering respiratory irritation, asthma attacks, and long-term lung damage.

In a significant breakthrough for environmental monitoring and public health, scientists from the Centre for Nano and Soft Matter Sciences (CeNS), Bengaluru, India, have developed an affordable and highly sensitive sensor capable of detecting sulfur dioxide (SO₂) gas at extremely low concentrations.
Sulfur dioxide, a toxic air pollutant primarily released from vehicle exhaust and industrial processes, is notorious for triggering respiratory irritation, asthma attacks, and long-term lung damage. Monitoring its presence in real time is essential, but existing technologies are often expensive, power-hungry, or ineffective at detecting the gas at trace levels.
To address this gap, the CeNS team, under the leadership of Dr. S. Angappane, has engineered a novel sensor by combining two metal oxides — nickel oxide (NiO) and neodymium nickelate (NdNiO₃). NiO serves as the receptor that captures SO₂ molecules, while NdNiO₃ acts as a transducer that converts the chemical interaction into an electrical signal. This innovative design enables the sensor to detect SO₂ at concentrations as low as 320 parts per billion (ppb), outperforming many commercial alternatives.
Speaking about the development, Dr. Angappane said in a media statement, “This sensor system not only advances the sensitivity benchmark but also brings real-time gas monitoring within reach for a wider range of users. It demonstrates how smart materials can provide practical solutions for real-world environmental challenges.”

The CeNS team has also built a portable prototype incorporating the sensor. It features a user-friendly threshold-triggered alert system with color-coded indicators: green for safe levels, yellow for warning, and red for danger. This visual approach ensures that even non-specialist users can understand and respond to pollution risks instantly. Its compact size and lightweight design make it ideal for deployment in industrial zones, urban neighborhoods, and enclosed environments requiring continuous air quality surveillance.
The sensor system was conceptualized and designed by Mr. Vishnu G Nath, with key contributions from Dr. Shalini Tomar, Mr. Nikhil N. Rao, Dr. Muhammed Safeer Naduvil Kovilakath, Dr. Neena S. John, Dr. Satadeep Bhattacharjee, and Prof. Seung-Cheol Lee. The research findings were recently published in the journal Small.
With this innovation, CeNS reinforces the role of advanced materials science in developing cost-effective technologies that protect both public health and the environment.
Health
Researchers Unveil 50-Cent DNA Sensors That Could Revolutionize Disease Diagnosis
The innovation lies in a low-cost electrochemical sensor stabilized with a polymer coating, which allows the device to be stored for months at high temperatures and used far from traditional lab settings

In a breakthrough that could make life-saving diagnostics accessible to millions, MIT researchers have developed a disposable, DNA-coated sensor capable of detecting diseases like cancer, HIV, and influenza — all for just 50 cents. The innovation lies in a low-cost electrochemical sensor stabilized with a polymer coating, which allows the device to be stored for months at high temperatures and used far from traditional lab settings.
At the heart of this sensor is a CRISPR-based enzyme system. When the sensor detects a target disease gene, the enzyme — acting like a molecular lawnmower — begins to shred DNA on the electrode, disrupting the electric signal and indicating a positive result.
“Our focus is on diagnostics that many people have limited access to, and our goal is to create a point-of-use sensor,” said Ariel Furst, MIT chemical engineering professor and senior author of the study, in a media statement. “People wouldn’t even need to be in a clinic to use it. You could do it at home.”
Previously, such sensors faced a major hurdle: the DNA coating degraded rapidly, requiring immediate use and refrigerated storage. Furst’s team overcame this by using polyvinyl alcohol (PVA) — a cheap and widely available polymer — to form a protective film over the DNA, significantly extending shelf life.
The sensors were tested to successfully detect PCA3, a prostate cancer biomarker found in urine, even after two months of storage at 150°F. The technology builds on Furst’s earlier work that enabled detection of HIV and HPV genetic material using similar CRISPR-based methods.
“This is the same core technology used in glucose meters, but adapted with programmable DNA,” said lead author Xingcheng Zhou, an MIT graduate student. “It’s inexpensive, portable, and extremely versatile.”
The team now aims to expand testing for other infectious and emerging diseases. They’ve been accepted into MIT’s delta v venture accelerator, signaling commercial interest and real-world application potential. The ability to ship sensors without refrigeration could be transformative for low-resource and remote settings.
“Our limitation before was that we had to make the sensors on site,” added Furst. “Now that we can protect them, we can ship them. That allows us to access a lot more rugged or non-ideal environments for testing.”
With further development, these pocket-sized DNA sensors could redefine early disease detection — from rural clinics to living rooms.
Health
Teak Leaf Extract Emerges as Eco-Friendly Shield Against Harmful Laser Rays
Raman Research Institute scientists unlock sustainable alternative for laser safety in line with green tech goals

In a significant step toward sustainable photonic technologies, scientists from the Raman Research Institute (RRI), an autonomous institute under the Department of Science and Technology (DST), Government of India, have discovered that teak leaf extract can serve as an effective, natural shield against harmful laser radiation. This breakthrough offers new potential for protecting both sensitive optical sensors and human eyes from high-intensity lasers used in medical, industrial, and defense applications.
The team has found that the otherwise discarded leaves of the teak tree (Tectona grandis L.f) are rich in anthocyanins, natural pigments responsible for their reddish-brown colour. When exposed to light, these pigments exhibit nonlinear optical (NLO) properties, allowing them to absorb intense laser beams—a key feature required for laser safety gear.
The discovery, recently published in the Journal of Photochemistry and Photobiology A: Chemistry, proposes a non-toxic, biodegradable, and cost-effective alternative to conventional synthetic materials like graphene and metal nanoparticles, which are often expensive and environmentally hazardous.
“Teak leaves are a rich source of natural pigments such as anthocyanin… We explored the potential of teak leaf extract as an eco-friendly alternative to synthetic dyes in the field of nonlinear optics,” said Beryl C, DST Women Scientist at RRI, in a media statement issued by the government.
To extract this natural dye, researchers dried and powdered teak leaves, soaked them in solvents, and processed the mixture using ultrasonication and centrifugation. The resulting reddish-brown liquid was then tested with green laser beams under continuous and pulsed conditions.
Using advanced techniques like Z-scan and Spatial Self-Phase Modulation (SSPM), the dye demonstrated reverse saturable absorption (RSA)—a rare and desirable trait where the material absorbs more light as the intensity increases, effectively acting as a self-regulating shield against laser exposure.
This development is particularly crucial as laser technologies become increasingly prevalent in everyday environments—from surgical devices and industrial cutters to military-grade systems. By offering a natural and renewable solution to a global safety challenge, the RRI team has opened the door to a future of eco-conscious optical safety equipment, such as laser-resistant eyewear, coatings, and sensor shields.
Researchers also indicated that further studies will focus on enhancing the stability and commercial usability of the dye for long-term deployment.
This innovation aligns with the principles of Industry 5.0, emphasizing human-centered and environmentally responsible technology, and showcases how indigenous, sustainable resources can play a pivotal role in global tech solutions.
-
Society5 months ago
Starliner crew challenge rhetoric, says they were never “stranded”
-
Space & Physics3 months ago
Could dark energy be a trick played by time?
-
Earth5 months ago
How IIT Kanpur is Paving the Way for a Solar-Powered Future in India’s Energy Transition
-
Space & Physics3 months ago
Sunita Williams aged less in space due to time dilation
-
Learning & Teaching5 months ago
Canine Cognitive Abilities: Memory, Intelligence, and Human Interaction
-
Women In Science4 months ago
Neena Gupta: Shaping the Future of Algebraic Geometry
-
Society5 months ago
Sustainable Farming: The Microgreens Model from Kerala, South India
-
Earth3 months ago
122 Forests, 3.2 Million Trees: How One Man Built the World’s Largest Miyawaki Forest