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Space & Physics

Scientists Use Light to Direct Movement in Starfish Egg Cells

By genetically engineering a light-sensitive version of this enzyme, the researchers were able to use light to direct the cell’s motion in precise patterns

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The study’s senior author, Nikta Fakhri, associate professor of physics at MIT. Credits:Photo: Adam Glanzman

The ability to control the behaviour of individual cells has long been a goal of scientists studying cell development. MIT researchers have now developed a method to manipulate how a single cell moves and changes shape, using light. This breakthrough, which could have far-reaching applications in synthetic biology and medicine, was demonstrated in egg cells from starfish—a common model for understanding cell behaviour during development.

The team, led by Nikta Fakhri, focused on an enzyme within the starfish egg cell that triggers a cascade of movements. By genetically engineering a light-sensitive version of this enzyme, the researchers were able to use light to direct the cell’s motion in precise patterns.

“We found that the light successfully triggered the enzyme, which in turn prompted the cells to jiggle and move in predictable patterns,” says Fakhri, an associate professor of physics at MIT. “For instance, we could stimulate cells to exhibit small pinches or sweeping contractions, depending on the pattern of light we induced. We could even shine light at specific points around a cell to stretch its shape from a circle to a square.”

The findings, set to be published in Nature Physics, open up exciting possibilities for future medical and synthetic cell applications. The researchers envision using this technology to design cells that could respond to light for therapeutic purposes, such as “patch” cells that contract to help close wounds or drug-delivering cells that release medication only when illuminated at specific locations in the body.

Fakhri continues, “By revealing how a light-activated switch can reshape cells in real time, we’re uncovering basic design principles for how living systems self-organize and evolve shape.”

The research team includes MIT’s Jinghui Liu, Yu-Chen Chao, and Tzer Han Tan, alongside collaborators from Ludwig Maximilian University of Munich, Saarland University, and the Whitehead Institute for Biomedical Research.

Exploring the Starfish Model

Fakhri’s group specializes in understanding the physical dynamics that drive cell growth, especially the role of symmetry in cell development. The starfish, known for its distinct stages of symmetry, is an ideal organism for studying the signalling processes that guide cell organization.

“A starfish is fascinating because it starts with a symmetrical cell and eventually develops into an adult with pentameral symmetry,” Fakhri explains. “There are many signalling events along the way that direct how the cell organizes itself into more complex structures.”

The team’s earlier research identified a key “circuitry” in the starfish egg cell that regulates its movement and shape. This circuitry involves an enzyme called GEF, which, when activated, triggers a protein called Rho. Rho plays a crucial role in regulating cell mechanics by binding to the cell’s membrane and initiating the formation of muscle-like fibres that enable the cell to contract and move.

Harnessing Light to Control Cell Movement

In this new study, the team turned to optogenetics, a technique that uses light to control genetically engineered cellular components. They created a light-sensitive version of the GEF enzyme and injected it into egg cells harvested from starfish. The cells, now capable of producing the light-sensitive enzyme, were placed under a microscope, and the researchers applied light in different patterns to observe how the cells responded.

By targeting specific areas of the cell with light, they were able to activate the enzyme, triggering the Rho protein to form fibers and cause the cell to move. This allowed the team to control the cell’s shape, even morphing it from a circle into a square. Additionally, they discovered that shining light in a single spot could initiate sweeping contractions within the cell, providing even more precise control over its behaviour.

“We realized this Rho-GEF circuitry is an excitable system, where a small, well-timed stimulus can trigger a large, all-or-nothing response,” Fakhri says. “By illuminating either the entire cell or just a small region, we can control how the cell responds and causes contraction or pinching.”

The researchers also developed a theoretical framework to predict how cells would change in response to light stimuli. This new understanding of cellular “excitability” could have important implications for fields like developmental biology, wound healing, and synthetic biology.

Future Applications in Synthetic Biology

“This work provides a blueprint for designing programmable synthetic cells,” Fakhri explains. “By controlling cell shape in real time, we can potentially design cells that perform specific tasks in the body when activated by light. This could lead to new biomedical applications, from targeted drug delivery to tissue repair.”

The ability to control cell behaviour with light opens up exciting possibilities for future research and applications, offering a new way to explore how cells shape themselves during development and how we might harness these processes for therapeutic use.

Space & Physics

MIT unveils an ultra-efficient 5G receiver that may supercharge future smart devices

A key innovation lies in the chip’s clever use of a phenomenon called the Miller effect, which allows small capacitors to perform like larger ones

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Image credit: Mohamed Hassan from Pixabay

A team of MIT researchers has developed a groundbreaking wireless receiver that could transform the future of Internet of Things (IoT) devices by dramatically improving energy efficiency and resilience to signal interference.

Designed for use in compact, battery-powered smart gadgets—like health monitors, environmental sensors, and industrial trackers—the new chip consumes less than a milliwatt of power and is roughly 30 times more resistant to certain types of interference than conventional receivers.

“This receiver could help expand the capabilities of IoT gadgets,” said Soroush Araei, an electrical engineering graduate student at MIT and lead author of the study, in a media statement. “Devices could become smaller, last longer on a battery, and work more reliably in crowded wireless environments like factory floors or smart cities.”

The chip, recently unveiled at the IEEE Radio Frequency Integrated Circuits Symposium, stands out for its novel use of passive filtering and ultra-small capacitors controlled by tiny switches. These switches require far less power than those typically found in existing IoT receivers.

A key innovation lies in the chip’s clever use of a phenomenon called the Miller effect, which allows small capacitors to perform like larger ones. This means the receiver achieves necessary filtering without relying on bulky components, keeping the circuit size under 0.05 square millimeters.

Credit: Courtesy of the researchers/MIT News

Traditional IoT receivers rely on fixed-frequency filters to block interference, but next-generation 5G-compatible devices need to operate across wider frequency ranges. The MIT design meets this demand using an innovative on-chip switch-capacitor network that blocks unwanted harmonic interference early in the signal chain—before it gets amplified and digitized.

Another critical breakthrough is a technique called bootstrap clocking, which ensures the miniature switches operate correctly even at a low power supply of just 0.6 volts. This helps maintain reliability without adding complex circuitry or draining battery life.

The chip’s minimalist design—using fewer and smaller components—also reduces signal leakage and manufacturing costs, making it well-suited for mass production.

Looking ahead, the MIT team is exploring ways to run the receiver without any dedicated power source—possibly by harvesting ambient energy from nearby Wi-Fi or Bluetooth signals.

The research was conducted by Araei alongside Mohammad Barzgari, Haibo Yang, and senior author Professor Negar Reiskarimian of MIT’s Microsystems Technology Laboratories.

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Society

Ahmedabad Plane Crash: The Science Behind Aircraft Take-Off -Understanding the Physics of Flight

Take-off is one of the most critical phases of flight, relying on the precise orchestration of aerodynamics, propulsion, and control systems. Here’s how it works:

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On June 12, 2025, a tragic aviation accident struck Ahmedabad, India when a regional passenger aircraft, Air India flight A1-171, crashed during take-off at Sardar Vallabhbhai Patel International Airport. According to preliminary reports, the incident resulted in over 200 confirmed casualties, including both passengers and crew members, and several others are critically injured. The aviation community and scientific world now turn their eyes not just toward the cause but also toward understanding the complex science behind what should have been a routine take-off.

How Do Aircraft Take Off?

Take-off is one of the most critical phases of flight, relying on the precise orchestration of aerodynamics, propulsion, and control systems. Here’s how it works:

1. Lift and Thrust

To leave the ground, an aircraft must generate lift, a force that counters gravity. This is achieved through the unique shape of the wing, called an airfoil, which creates a pressure difference — higher pressure under the wing and lower pressure above — according to Bernoulli’s Principle and Newton’s Third Law.

Simultaneously, engines provide thrust, propelling the aircraft forward. Most commercial jets use turbofan engines, which accelerate air through turbines to generate power.

2. Critical Speeds

Before takeoff, pilots calculate critical speeds:

  • V1 (Decision Speed): The last moment a takeoff can be safely aborted.
  • Vr (Rotation Speed): The speed at which the pilot begins to lift the nose.
  • V2 (Takeoff Safety Speed): The speed needed to climb safely even if one engine fails.

If anything disrupts this process — like bird strikes, engine failure, or runway obstructions — the results can be catastrophic.

Environmental and Mechanical Challenges

Factors like wind shear, runway surface condition, mechanical integrity, or pilot error can interfere with safe take-off. Investigators will be analyzing these very aspects in the Ahmedabad case.

The Bigger Picture

Take-off accounts for a small fraction of total flight time but is disproportionately associated with accidents — approximately 14% of all aviation accidents occur during take-off or initial climb.

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Space & Physics

MIT claims breakthrough in simulating physics of squishy, elastic materials

In a series of experiments, the new solver demonstrated its ability to simulate a diverse array of elastic behaviors, ranging from bouncing geometric shapes to soft, squishy characters

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Image credit: Courtesy of researchers

Researchers at MIT claim to have unveiled a novel physics-based simulation method that significantly improves stability and accuracy when modeling elastic materials — a key development for industries spanning animation, engineering, and digital fabrication.

In a series of experiments, the new solver demonstrated its ability to simulate a diverse array of elastic behaviors, ranging from bouncing geometric shapes to soft, squishy characters. Crucially, it maintained important physical properties and remained stable over long periods of time — an area where many existing methods falter.

Other simulation techniques frequently struggled in tests: some became unstable and caused erratic behavior, while others introduced excessive damping that distorted the motion. In contrast, the new method preserved elasticity without compromising reliability.

“Because our method demonstrates more stability, it can give animators more reliability and confidence when simulating anything elastic, whether it’s something from the real world or even something completely imaginary,” Leticia Mattos Da Silva, a graduate student at MIT’s Department of Electrical Engineering and Computer Science, said in a media statement.

Their study, though not yet peer-reviewed or published, will be presented at the August proceedings of the SIGGRAPH conference in Vancouver, Canada.

While the solver does not prioritize speed as aggressively as some tools, it avoids the accuracy and robustness trade-offs often associated with faster methods. It also sidesteps the complexity of nonlinear solvers, which are commonly used in physics-based approaches but are often sensitive and prone to failure.

Looking ahead, the research team aims to reduce computational costs and broaden the solver’s applications. One promising direction is in engineering and fabrication, where accurate elastic simulations could enhance the design of real-world products such as garments, medical devices, and toys.

“We were able to revive an old class of integrators in our work. My guess is there are other examples where researchers can revisit a problem to find a hidden convexity structure that could offer a lot of advantages,” Mattos Da Silva added.

The study opens new possibilities not only for digital content creation but also for practical design fields that rely on predictive simulations of flexible materials.

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