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Genetics and regional health disparities significantly influence stroke risk

Stroke is one of the leading causes of human death globally. Stroke affects more than 101 million people worldwide and more than 6.55 million people died from it in 2019

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A new study reveals that genetic factors and various medical conditions in different ethnic groups are crucial in increasing the risk of stroke. This was revealed in a study conducted by Moinak Banerjee, a researcher associated with the Department of Neurobiology at the Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB).

RGCB is a research institute in Thiruvananthapuram, the capital of India’s southern state Kerala, and the instirtue is exclusively devoted to research in Molecular Biology and Biotechnology.

According to the study, the factors that cause stroke differ in different regional and population groups. A series of internal chemical changes in humans have been found to increase the risk of stroke in the United States and Europe. Meanwhile, in Asian and African regions, changes in blood vessels in humans have been shown to be a major driver of stroke. This shows that stroke risk and outcome vary by region and genetic factors.

The underlying genetic factors are very critical in determining and defining the regional variations in influencing the stroke and its comorbidities which, in turn, can define the burden of stroke,” observes the study.

The study was published in the biomedical journal eLife. The study’s findings are based on data collected for stroke and its risk during 2009-19. It is one of the largest studies ever conducted globally, involving 204 countries. 11 different conditions of paralysis were studied. Stroke, its subtypes such as ischemic stroke (IS), intracranial hemorrhage (ICH), and other comorbidities such as ischemic heart disease (IHD), type 1–type 2 diabetes, chronic kidney disease, high blood pressure, high body mass index (BMI), and high LDL and cholesterol have been studied.

Stroke is one of the leading causes of human death globally. Stroke affects more than 101 million people worldwide and more than 6.55 million people died from it in 2019. Prof. Chandrabhas Narayana, Director, RGCB, said that this is an important study that will contribute greatly in preventing stroke and making treatment and prevention more efficient. The study points out that while most public health researchers interpret stroke from a socio-economic perspective, biomedical researchers conduct separate investigations and find causes. Prevention of stroke requires the identification and management of other medical conditions. The study emphasizes the need to understand regional and genetic differences. This will help health policy makers understand areas of concern, he added

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EDUNEWS & VIEWS

Will Canada remain a hub for Indian students amidst new restrictions?

New restrictions on student visas and work permits have sparked debate about the future of Canada as a preferred educational hub

Dipin Damodharan

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Image credit: Jose Jacob

As Canada continues to position itself as a leading destination for international students, recent policy changes are raising concerns about its appeal, particularly among Indian students. New restrictions on student visas and work permits have sparked debate about the future of Canada as a preferred educational hub.

In the past decade, Canada has seen a surge in international students, with Indian nationals being a significant contributor to this growth. According to recent statistics, Indian students constitute one of the largest groups of international students in Canada. India sent 225,000 students to Canada, a number that rose to 278,000 in 2023. For the first half of 2024, the count has reached 100,000 students. However, new regulations imposed by Canadian authorities aim to address issues of overstaying and unauthorized work, potentially impacting this vibrant demographic.

Policy Changes and Immediate Implications

The Canadian government’s recent policy changes include stricter requirements for student visas and modifications to work permit conditions. Under the new regulations, international students will face more rigorous checks before their applications are approved. Additionally, there are enhanced restrictions on the type and amount of work international students can undertake while studying.

The new rules mandate that students must now provide more detailed evidence of financial stability and academic intentions. Moreover, there will be an increase in the frequency of status reviews and a more stringent enforcement of existing work permit regulations. These measures are designed to curb the misuse of student visas and ensure that students adhere to their intended study programs.

For many Indian students, these changes represent a significant shift in their academic and professional plans. “The new restrictions have created a wave of uncertainty among students planning to study in Canada,” says Arjun Patel, a recent high school graduate who was preparing to enroll in a Canadian university. “We’re concerned about how these policies will affect our ability to work part-time and support ourselves while studying.”

Impact on Current and Prospective Students

For current international students in Canada, the immediate impact of these policy changes includes increased stress over visa renewals and job security. Many students who rely on part-time work to support their education and living expenses might find themselves restricted by the new regulations. This could lead to financial strain and affect their academic performance.

Jose Jacob, a Canadian immigrant, attributes the recent restrictions on international students in Canada to a combination of political and economic factors. “Education is a billion-dollar industry for Canada,” Jacob notes. “When I arrived here, and for many years since, community colleges have been major promoters of study abroad programs. Many of these institutions are private community colleges operating like businesses. More foreign students mean higher fees, which significantly boosts the industry.”

Jose Jacob

Jacob also points out that the Trudeau government has traditionally been supportive of immigration. Under Prime Minister Justin Trudeau, Canada has welcomed international students, offered residency, and invited refugees. “Trudeau’s policies are driven by the immigrant vote bank,” Jacob explains.

Prospective students face the challenge of navigating a more complex visa application process. The enhanced scrutiny may lead to longer processing times and additional paperwork, potentially causing delays in starting their studies. “The increased documentation requirements and the possibility of visa rejections have made the application process more daunting,” notes Rina Sharma, a prospective student from Delhi. “We’re concerned about how these changes will affect our plans and whether it will be worth the investment.”

Canada’s Commitment to International Education

Despite the new restrictions, Canadian officials have reiterated their commitment to international education. They emphasize that the changes are intended to preserve the integrity of the student visa system and ensure that students are genuinely pursuing their educational goals. The recent decision to impose restrictions on foreign students came amid significant domestic protests. “The decision was announced during a period of considerable political pressure,” Jose Jacob adds. He also highlights that the rising cost of living and housing shortages in places such as Ontario have contributed to the government’s decision. “The surge in housing prices and the increase in the cost of goods led to saturation,” he says.

“Canada remains dedicated to attracting top talent from around the world,” says, a spokesperson of a global education consulting group. “These policy adjustments are necessary to prevent abuse of the system and to ensure that our programs continue to benefit students who are committed to their studies.”

Moreover, educational institutions in Canada are working to support international students through these transitions. Many universities are enhancing their advisory services to help students navigate the new regulations and adjust their plans accordingly.

The Future of Canada as an Educational Destination

As Canada navigates these new policy changes, it faces the challenge of maintaining its status as a leading destination for international students. While the regulations are designed to address specific issues, they must balance the need for oversight with the desire to remain an attractive option for students worldwide.

For Indian students, the changing landscape presents both challenges and opportunities. While the new restrictions may complicate the immediate future, Canada’s robust educational infrastructure and diverse academic offerings continue to make it a compelling choice for many. The key will be how well the country can adapt to these changes while continuing to offer a supportive and enriching environment for international learners.

Image credit: Jose Jacob

Jacob suggests that these new regulations are also aimed at curbing fraudulent courses. “Previously, the U.S. was marketed to Europeans as the ‘Land of Opportunities,’ attracting early settlers. Similarly, Canada has been marketed as a land of opportunity for Indian students. Community colleges have collaborated with local educational consulting agencies to promote this image. However, the situation has become too saturated. Technical jobs are in higher demand now, and Canada remains a good option for students in those fields.”

Jacob also warns prospective students about the financial realities of living in Canada. “For those coming here to make money, it’s important to understand that it’s not like the Gulf countries. Taxes are very high—13 percent on everything,” he advises. “It’s crucial to be aware of these factors before making the move.”

To sum up, as Canada adjusts its policies regarding international students, it will be crucial for both the government and educational institutions to address the concerns of students and ensure that the country remains a welcoming and viable destination for those seeking higher education. The coming months will reveal whether Canada can sustain its reputation as a global education hub amidst these evolving regulations.

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Repurposed antidepressant shows promise as cost-effective treatment for breast cancer

The research, led by Dr. Asis Bala, reveals that Selegiline, a monoamine oxidase (MAO) inhibitor, could be repurposed as an anticancer therapeutic.

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Image by Waldryano from Pixabay

In a groundbreaking study, researchers at the Institute of Advanced Study in Science and Technology (IASST) in Guwahati, India, have discovered that Selegiline, an antidepressant drug, may offer a cost-effective alternative for breast cancer treatment. The research, led by Dr. Asis Bala, reveals that Selegiline, a monoamine oxidase (MAO) inhibitor, could be repurposed as an anticancer therapeutic.

The team’s findings, published in the journal Medical Oncology, demonstrate that Selegiline interacts with ten genes associated with various cancers. Their preliminary tests on six different cancer cell lines showed Selegiline’s efficacy in targeting both estrogen and progesterone-positive (ER+ & PR+) and triple-negative breast cancer (TNBC) cells. This research group has shown that Selegiline (L-deprenyl), an antidepressant drug from a class of drugs called monoamine oxidase (MAO) inhibitors, might be applied as anticancer therapeutics for breast cancer.

Unlike conventional therapies that rely on reactive oxygen species (ROS) to induce cell death, Selegiline operates through a different mechanism. It has been shown to inhibit protein kinase C phosphorylation, a process believed to be involved in its cancer-fighting effects.

Selegiline showed integrated networking with genes and diseases of different cancers. It also showed the inhibitory effect of PKC phosphorylation and ROS-independent apoptosis in breast cancer cells.

This novel application of Selegiline marks a significant step forward in cancer research. The study’s results highlight the need for further investigation into the drug’s in vivo efficacy, optimal dosing, and potential side effects. This approach could pave the way for more accessible and affordable breast cancer treatments in the future.

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India’s richest man wants to democratise AI with ‘Jio Brain’

Jio is developing a full suite of tools and platforms under the ‘Jio Brain’ initiative, which will span the entire AI lifecycle

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Image credit: Pixabay

In a groundbreaking announcement at the 47th Annual General Meeting of Reliance Industries Limited on August, 29, India’s richest man, Mukesh Ambani, unveiled his ambitious plans to democratise artificial intelligence (AI) across the nation. The centrepiece of this vision is the ‘Jio Brain’ initiative, a comprehensive platform designed to bring “AI everywhere for everyone” in India.

Addressing shareholders, Ambani, the Chairman and Managing Director of Reliance Industries, emphasized the importance of making AI accessible and affordable to all Indians. “We are committed to ensuring that powerful AI models and services are available to everyone in India at the most affordable prices,” said Ambani.

Mukesh Ambani/Image credit: RIL

He revealed that Jio is developing a full suite of tools and platforms under the ‘Jio Brain’ initiative, which will span the entire AI life-cycle. This platform is set to become a powerful AI service that not only benefits Reliance but will also be offered to other enterprises.

A key part of this strategy is the creation of a national AI infrastructure, with plans to establish gigawatt-scale AI-ready data centres in Jamnagar, a city in the western Indian state of Gujarat . These centres will be powered entirely by Reliance’s green energy, reflecting the company’s commitment to sustainability and a greener future. “Our aim is to create the world’s lowest AI inferencing cost right here in India,” Ambani stated, highlighting the potential for India to become a global leader in AI applications.

To further support this vision, Jio will leverage its expertise in infrastructure, networking, operations, software, and data, in collaboration with global partners. The ultimate goal is to make AI applications more affordable in India than anywhere else, enabling widespread adoption across various sectors.

In addition to these developments, Ambani announced the Jio AI-Cloud Welcome offer, which includes up to 100 GB of free cloud storage. This offer is designed to support the ‘AI Everywhere for Everyone’ vision, allowing users to securely store and access their digital content and data with ease.

With ‘Jio Brain’ and its associated initiatives, Mukesh Ambani is positioning India at the forefront of the global AI revolution, democratising access to cutting-edge technology and setting the stage for a new era of connected intelligence in the country.

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