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Oxidative Stress Linked to Development of Cancer, Cardiovascular Diseases: Study

This breakthrough could pave the way for new therapeutic approaches targeting oxidative stress, offering hope for the treatment of a wide range of diseases where antioxidant responses are vital.

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Image credit: Pixabay

A new study by researchers at the Rajiv Gandhi Centre for Biotechnology (RGCB), Kerala, India, has revealed a crucial connection between mRNA processing and oxidative stress response, shedding light on a condition that plays a pivotal role in the development of various diseases, including cancer, cardiovascular disorders, neurological diseases, and diabetes, as well as aging. The research emphasizes the critical impact of oxidative stress, particularly in the heart, which contributes to several health conditions such as hypertension, heart failure, hypoxia, ischemia-reperfusion injury, atherosclerosis, and hypertrophy (excessive development of an organ or tissue).

The team of scientists at RGCB, led by Dr. Rakesh S. Laishram (Scientist), Dr. Feba Shaji, and Dr. Jamshaid Ali, discovered that during oxidative stress, when reactive oxidative species exceed the cell’s capacity to neutralize them, the production of antioxidant proteins is boosted. This is achieved by enhancing the fidelity of RNA processing, a mechanism that helps cells combat oxidative stress. The study, published in Redox Biology journal, uncovers this novel pathway in gene expression.

Dr Rakesh S Laishram lead scientist along with a team consisting of PhD scholar Dr Feba Shaji from RGCB-BRIC came up with the path breaking findings identifying RNA processing mediated regulation of oxidative stress response.

In the gene expression process, DNA is transcribed into RNA, which is then translated into proteins responsible for carrying out various cellular functions. Manipulations in these pathways—whether through DNA, RNA, or proteins—can alter gene expression depending on the cellular state. RNA processing, a key pathway controlling gene expression, involves the cleavage of RNA. Interestingly, this cleavage is not always precise, with multiple potential cleavage sites, a phenomenon known as cleavage heterogeneity.

“Controlling oxidative stress is crucial for maintaining cellular health and preventing human diseases. One key way cells regulate oxidative stress is by controlling gene expression through alterations in DNA, RNA, or proteins,” says Dr. Laishram, highlighting the importance of this research in understanding how cells respond to oxidative stress through imprecisions in RNA processing. “This underscores the therapeutic potential of targeting cleavage precision in RNA to mitigate oxidative stress and its associated pathologies.”

Dr. Chandrabhas Narayana, Director of RGCB, described it a significant contribution to understanding how antioxidants influence the pathogenesis and development of diseases.

While previous research had not fully elucidated the mechanism, regulation, or biological implications of cleavage imprecision, this study challenges the common perception that such imprecision is merely error-prone. Dr. Shaji and her team discovered that cleavage imprecision is tightly regulated, playing a critical role in controlling gene expression in response to oxidative stress. Key oxidative stress response genes, such as NQO1, HMOX1, PRDX1, and CAT, show higher heterogeneity compared to genes involved in non-stress responses. Furthermore, the number of cleavage sites on these RNA molecules is reduced, enabling cells to better respond to oxidative stresses.

The RGCB researchers have now shown that this heterogeneity is driven by a fidelity cleavage complex that cleaves RNA at a primary site during oxidative stress. This study marks the first example of the biological significance of cleavage imprecision, which regulates gene expression in the cellular oxidative stress response. The findings offer a novel mechanism of antioxidant response, distinct from other oxidative stress pathways, with far-reaching implications for understanding the pathogenesis of diseases such as cancer, cardiovascular conditions, inflammation, neurodegeneration, aging, and diabetes.

This breakthrough could pave the way for new therapeutic approaches targeting oxidative stress, offering hope for the treatment of a wide range of diseases where antioxidant responses are vital.

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Researchers Develop Low-Cost Sensor for Real-Time Detection of Toxic Sulfur Dioxide Gas

Sulfur dioxide, a toxic air pollutant primarily released from vehicle exhaust and industrial processes, is notorious for triggering respiratory irritation, asthma attacks, and long-term lung damage.

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In a significant breakthrough for environmental monitoring and public health, scientists from the Centre for Nano and Soft Matter Sciences (CeNS), Bengaluru, India, have developed an affordable and highly sensitive sensor capable of detecting sulfur dioxide (SO₂) gas at extremely low concentrations.

Sulfur dioxide, a toxic air pollutant primarily released from vehicle exhaust and industrial processes, is notorious for triggering respiratory irritation, asthma attacks, and long-term lung damage. Monitoring its presence in real time is essential, but existing technologies are often expensive, power-hungry, or ineffective at detecting the gas at trace levels.

To address this gap, the CeNS team, under the leadership of Dr. S. Angappane, has engineered a novel sensor by combining two metal oxides — nickel oxide (NiO) and neodymium nickelate (NdNiO₃). NiO serves as the receptor that captures SO₂ molecules, while NdNiO₃ acts as a transducer that converts the chemical interaction into an electrical signal. This innovative design enables the sensor to detect SO₂ at concentrations as low as 320 parts per billion (ppb), outperforming many commercial alternatives.

Speaking about the development, Dr. Angappane said in a media statement, “This sensor system not only advances the sensitivity benchmark but also brings real-time gas monitoring within reach for a wider range of users. It demonstrates how smart materials can provide practical solutions for real-world environmental challenges.”

Threshold-triggered sensor response in a) Safe state, b) Warning state, and c) Danger state. Image credit: PIB

The CeNS team has also built a portable prototype incorporating the sensor. It features a user-friendly threshold-triggered alert system with color-coded indicators: green for safe levels, yellow for warning, and red for danger. This visual approach ensures that even non-specialist users can understand and respond to pollution risks instantly. Its compact size and lightweight design make it ideal for deployment in industrial zones, urban neighborhoods, and enclosed environments requiring continuous air quality surveillance.

The sensor system was conceptualized and designed by Mr. Vishnu G Nath, with key contributions from Dr. Shalini Tomar, Mr. Nikhil N. Rao, Dr. Muhammed Safeer Naduvil Kovilakath, Dr. Neena S. John, Dr. Satadeep Bhattacharjee, and Prof. Seung-Cheol Lee. The research findings were recently published in the journal Small.

With this innovation, CeNS reinforces the role of advanced materials science in developing cost-effective technologies that protect both public health and the environment.

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Researchers Unveil 50-Cent DNA Sensors That Could Revolutionize Disease Diagnosis

The innovation lies in a low-cost electrochemical sensor stabilized with a polymer coating, which allows the device to be stored for months at high temperatures and used far from traditional lab settings

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Credit: Courtesy of the researchers; edited by MIT News

In a breakthrough that could make life-saving diagnostics accessible to millions, MIT researchers have developed a disposable, DNA-coated sensor capable of detecting diseases like cancer, HIV, and influenza — all for just 50 cents. The innovation lies in a low-cost electrochemical sensor stabilized with a polymer coating, which allows the device to be stored for months at high temperatures and used far from traditional lab settings.

At the heart of this sensor is a CRISPR-based enzyme system. When the sensor detects a target disease gene, the enzyme — acting like a molecular lawnmower — begins to shred DNA on the electrode, disrupting the electric signal and indicating a positive result.

“Our focus is on diagnostics that many people have limited access to, and our goal is to create a point-of-use sensor,” said Ariel Furst, MIT chemical engineering professor and senior author of the study, in a media statement. “People wouldn’t even need to be in a clinic to use it. You could do it at home.”

Previously, such sensors faced a major hurdle: the DNA coating degraded rapidly, requiring immediate use and refrigerated storage. Furst’s team overcame this by using polyvinyl alcohol (PVA) — a cheap and widely available polymer — to form a protective film over the DNA, significantly extending shelf life.

The sensors were tested to successfully detect PCA3, a prostate cancer biomarker found in urine, even after two months of storage at 150°F. The technology builds on Furst’s earlier work that enabled detection of HIV and HPV genetic material using similar CRISPR-based methods.

“This is the same core technology used in glucose meters, but adapted with programmable DNA,” said lead author Xingcheng Zhou, an MIT graduate student. “It’s inexpensive, portable, and extremely versatile.”

The team now aims to expand testing for other infectious and emerging diseases. They’ve been accepted into MIT’s delta v venture accelerator, signaling commercial interest and real-world application potential. The ability to ship sensors without refrigeration could be transformative for low-resource and remote settings.

“Our limitation before was that we had to make the sensors on site,” added Furst. “Now that we can protect them, we can ship them. That allows us to access a lot more rugged or non-ideal environments for testing.”

With further development, these pocket-sized DNA sensors could redefine early disease detection — from rural clinics to living rooms.

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Teak Leaf Extract Emerges as Eco-Friendly Shield Against Harmful Laser Rays

Raman Research Institute scientists unlock sustainable alternative for laser safety in line with green tech goals

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In a significant step toward sustainable photonic technologies, scientists from the Raman Research Institute (RRI), an autonomous institute under the Department of Science and Technology (DST), Government of India, have discovered that teak leaf extract can serve as an effective, natural shield against harmful laser radiation. This breakthrough offers new potential for protecting both sensitive optical sensors and human eyes from high-intensity lasers used in medical, industrial, and defense applications.

The team has found that the otherwise discarded leaves of the teak tree (Tectona grandis L.f) are rich in anthocyanins, natural pigments responsible for their reddish-brown colour. When exposed to light, these pigments exhibit nonlinear optical (NLO) properties, allowing them to absorb intense laser beams—a key feature required for laser safety gear.

The discovery, recently published in the Journal of Photochemistry and Photobiology A: Chemistry, proposes a non-toxic, biodegradable, and cost-effective alternative to conventional synthetic materials like graphene and metal nanoparticles, which are often expensive and environmentally hazardous.

“Teak leaves are a rich source of natural pigments such as anthocyanin… We explored the potential of teak leaf extract as an eco-friendly alternative to synthetic dyes in the field of nonlinear optics,” said Beryl C, DST Women Scientist at RRI, in a media statement issued by the government.

To extract this natural dye, researchers dried and powdered teak leaves, soaked them in solvents, and processed the mixture using ultrasonication and centrifugation. The resulting reddish-brown liquid was then tested with green laser beams under continuous and pulsed conditions.

Using advanced techniques like Z-scan and Spatial Self-Phase Modulation (SSPM), the dye demonstrated reverse saturable absorption (RSA)—a rare and desirable trait where the material absorbs more light as the intensity increases, effectively acting as a self-regulating shield against laser exposure.

This development is particularly crucial as laser technologies become increasingly prevalent in everyday environments—from surgical devices and industrial cutters to military-grade systems. By offering a natural and renewable solution to a global safety challenge, the RRI team has opened the door to a future of eco-conscious optical safety equipment, such as laser-resistant eyewear, coatings, and sensor shields.

Researchers also indicated that further studies will focus on enhancing the stability and commercial usability of the dye for long-term deployment.

This innovation aligns with the principles of Industry 5.0, emphasizing human-centered and environmentally responsible technology, and showcases how indigenous, sustainable resources can play a pivotal role in global tech solutions.

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