The Sciences
Human Cell Atlas Project could transform healthcare, says Sarah Amalia Teichmann
Human Cell Atlas has the potential to help us engineer cells for research and therapeutic purposes

Sarah Amalia Teichmann, a prominent scientist in cellular genetics and stem cell medicine, has been optimistic about the wide potential of the Human Cell Atlas (HCA) project, which she leads, to revolutionize disease diagnosis, treatment, and monitoring. While speaking at the BRIC-Rajiv Gandhi Centre for Biotechnology (RGCB), Teichmann shared insights into how the project could pave the way for engineering cells for research and therapeutic purposes.
Sarah Teichmann is also the current India Academy of Sciences Raman Chair.
“Human Cell Atlas has the potential to help us engineer cells for research and therapeutic purposes. For utilizing this potential, we first need to understand the molecular basis of cells in our body and define the cell types present. If we can achieve this, we have the potential to restore tissues, engineer cells, and that would be a revolution,” Teichmann said.
Teichmann, who also holds the Chair of Stem Cell Medicine at the University of Cambridge, explained that the mission of HCA is to create a comprehensive reference map of human cell types and properties. “This map is a basis for understanding our bodies, our physiology, tissue function, and provides new insights for diagnosing, monitoring, and treating diseases,” she added.
The HCA, a global initiative co-founded by Teichmann and her team in 2016, aims to create detailed reference maps of all human cells. The project focuses on mapping healthy human cells to drive biomedical advancements. “With this reference map, we can compare and integrate disease data with a healthy reference state of our cells and understand in detail what changes are occurring,” Teichmann explained.
One key area of the project’s impact is in understanding viral interactions. Teichmann discussed how HCA can serve as a guidebook for viral entry points in humans, shedding light on important biological questions related to rare and common diseases, hormone receptors, and drug targets. “This knowledge can enable us to ask questions about viral entry factors, gene expressions involved in diseases, and drug-related side effects,” she said, referring to her research during the COVID-19 pandemic.
Teichmann expressed confidence that the collaborative efforts behind the HCA, involving scientists globally—including in India—will lead to significant biomedical breakthroughs. She added, “This project will have a huge impact in biomedical advancement.”
The HCA’s progress has already been marked by significant milestones, including the publication of the first draft of the human cell atlas in Nature, showcasing 40 scientific discoveries.
The Raman Chair, established by the Government of India in 1972 in memory of Sir C.V. Raman, has been held by distinguished scientists such as Nobel laureates Prof. J.B. Goodenough, Prof. Harold E. Varmus, and Prof. Dorothy Hodgkin.
Society
How India’s Richest Man Remembers This Chemical Engineer
Here are the four key insights Mukesh Ambani shared about renowned chemical engineer Prof. M M Sharma:

At the launch of the biography Divine Scientist chronicling the life of legendary Indian chemical engineer Prof. Man Mohan Sharma, Mukesh Ambani, CMD of Reliance Industries, offered a moving tribute that captured the intellect, values, and national impact of his former teacher.
Prof. Sharma is a renowned chemical engineer, who became the first Indian engineer to be elected as a Fellow of Royal Society, the UK in 1990.
Here are the four key insights Ambani shared about Prof. Sharma:
1. The Alchemist of Minds
Ambani recalled how Prof. Sharma transformed his understanding of chemical engineering — and leadership. “He had the power to convert curiosity into knowledge, knowledge into commercial value, and both into everlasting wisdom,” he said. Choosing ICT over IIT Bombay, Ambani said Sharma’s first lecture confirmed he’d made the right decision.
2. Master of ‘Economics of Chemistry’
“He wasn’t just a scientist — he taught us how molecules make money,” said Ambani. He fondly remembered calling Sharma a “Bania chemical engineering professor” for blending scientific brilliance with business sense — a philosophy that informed Reliance’s rise in the petrochemicals industry.
3. Sustainability Visionary
Long before sustainability became a buzzword, Prof. Sharma taught his students to turn every ‘by-product’ into a ‘co-product’. “He insisted nothing should be wasted,” said Ambani. That vision shaped Reliance’s integrated manufacturing strategy, from crude oil to consumer products.
4. A Silent Architect of Economic Reforms
Prof. Sharma wasn’t just a scholar — he was a behind-the-scenes changemaker. Ambani revealed how Sharma, alongside his father Dhirubhai Ambani, lobbied for deregulating India’s chemical industry. “He told policymakers: if you want India to grow, end the license raj and build scale,” said Ambani. “He is not just our Guru — he is a Rashtra Guru.”
The emotional address underscored the enduring influence of a teacher whose lessons extend far beyond the classroom — into boardrooms, factories, and the future of India.
Earth
How Tuna and Swordfish Hunt in the Deep; MIT Oceanographers find the answer
A new study reveals that tuna and swordfish are making regular, long-distance plunges into the twilight zone, a mysterious and dark layer of the ocean, to fill their stomachs

Imagine diving into the ocean’s depths, descending further than the eye can see, into a cold, almost completely dark world where every movement feels like a gamble. For some of the ocean’s most formidable predators—like tuna and swordfish—this is no mere adventure; it’s a necessity. A new study reveals that these apex hunters are making regular, long-distance plunges into the twilight zone, a mysterious and dark layer of the ocean, to fill their stomachs. And what they’re finding there could change the way we think about ocean ecosystems and the future of commercial fishing.
For decades, oceanographers knew that large fish like tuna and swordfish occasionally ventured into the depths of the ocean, but the purpose of these dives remained unclear. Were these predators hunting for food, or were they just exploring? A recent breakthrough by MIT oceanographers has answered that question—and the results are more astonishing than anyone could have imagined.

In a pioneering study published in ICES Journal of Marine Science, an MIT team led by Ciara Willis has found that these fish are relying heavily on the twilight zone, a dark, cold layer between 200 and 1,000 meters below the surface, for as much as 60% of their diet. This discovery reveals a much deeper connection to this enigmatic zone than scientists previously realized.
“We’ve known for a long time that these fish and many other predators feed on twilight zone prey,” says Willis, a postdoc at the Woods Hole Oceanographic Institution, in a press statement. “But the extent to which they rely on this deep-sea food web for their diet has been unclear.”
The Hidden Feast
The twilight zone—often overlooked in marine research—has been gaining attention for its rich ecosystem. It’s a vast, underexplored region teeming with strange creatures, from tiny lanternfish to massive squid, all adapted to live without sunlight. While the surface waters are teeming with life, they offer less concentrated food for large predators. By contrast, the twilight zone is like a dense buffet, providing predators like bigeye tuna, yellowfin tuna, and swordfish a more reliable food source.
“This is a really understudied region of the ocean, and it’s filled with all these fantastic, weird animals,” Willis says. “We call it the ‘deep ocean buffet.’”
The deep sea creatures in the twilight zone have evolved to migrate vertically—swimming to the surface to feed at night and returning to the depths by day to avoid predators. For the big predators of the open ocean, this behavior creates a prime opportunity to feast. Bigeye tuna, yellowfin tuna, and swordfish dive regularly into these depths to hunt. But until recently, scientists didn’t know just how important this food source truly was.
“We saw the bigeye tuna were far and away the most consistent in where they got their food from,” Willis explains. “The swordfish and yellowfin tuna were more variable, meaning that if large-scale fishing were to target the twilight zone, bigeye tuna might be the ones most at risk.”
The Price of Overfishing the Deep
This discovery comes at a critical time. The growing interest in commercial fishing in the twilight zone, despite its often unpalatable fish species, has raised alarms. These creatures are increasingly being harvested for fishmeal and fish oil, products commonly used in animal feed and other industries. However, as researchers point out, this could have dire consequences for tuna and swordfish populations.
“There is increasing interest in commercial fishing in the ocean’s twilight zone,” says Willis. “If we start heavily fishing that layer of the ocean, our study suggests that could have profound implications for tuna and swordfish, which are highly reliant on this region.”
The team’s findings underscore the need for careful management of the twilight zone’s resources. Given that tuna and swordfish rely on this zone for up to 60% of their food, disruptions to the ecosystem here could have cascading effects on the open ocean and the global fishing industry.
“Predatory fish like tunas have a 50% reliance on twilight zone food webs,” Willis warns. “If we start heavily fishing in that region, it could lead to uncertainty around the profitability of tuna fisheries.”
As the twilight zone becomes a target for increasing commercial interest, scientists are calling for greater caution in how we approach the deep ocean’s complex food web. What lies in the shadows of the ocean’s depths may be far more crucial to our marine ecosystems than anyone has realized.
Health
UFS study finds emerging pathogen inside brown locusts
Study Reveals Brown Locusts as Carriers of Pathogenic Yeasts Linked to Human Infections

A new study conducted by researchers from the University of the Free State (UFS), the National Health Laboratory Service, and the University of Venda has revealed for the first time that common brown locusts can carry pathogenic yeasts, including Candida auris, a fungus capable of causing severe infections in humans, particularly in individuals with weakened immune systems or those seriously ill.
The study, titled South African brown locusts, Locustana pardalina, hosts fluconazole-resistant, Candidozyma (Candida) auris (Clade III), uncovers the presence of the disease-causing yeast C. auris in the digestive tracts of locusts. This discovery highlights the potential for locusts to spread this emerging pathogen. The research began in April 2022, with 20 adult locusts collected during a significant locust outbreak in the semi-arid Eastern Karoo region of the Eastern Cape, which lasted from September 2021 to May 2022. The study is currently under peer review.
According to Prof. Carlien Pohl-Albertyn, National Research Foundation (NRF) SARChI Research Chair in Pathogenic Yeasts, the researchers isolated three strains of C. auris from different locusts, two of which also contained strains of Candida orthopsilosis, another potentially pathogenic yeast. “The fact that we were able to isolate C. auris from 15% of the sampled locusts, using non-selective media and a non-restrictive temperature of 30°C, may indicate that C. auris is abundant in the locusts and that specific selective isolation is not mandatory,” said Prof. Pohl-Albertyn.

The study also found C. auris in both the fore- and hindguts of the locusts. The foregut, responsible for food intake and partial digestion, likely serves as the entry point for the yeast via the locust’s feeding activities. The hindgut confirmed that C. auris can survive digestion and may be excreted back into the environment through faeces.
While C. auris poses a significant risk to individuals with compromised immune systems, Prof. Pohl-Albertyn emphasized that healthy humans are not at great risk. “There is currently no proof that ingestion may be harmful to them,” she explained. However, she warned that the yeast could pose dangers to immunocompromised individuals, even though few people in South Africa are in direct contact with locusts.
One of the C. auris strains studied in-depth showed decreased susceptibility to fluconazole, a common antifungal drug, underscoring the need for new antifungal treatments. “This highlights the urgent need to discover and develop new antifungal drugs,” Prof. Pohl-Albertyn added.
The study also raises concerns about how locusts could potentially spread C. auris to other animals, such as birds, and, in some regions, even humans. “The fact that locusts are a food source for other animals could lead to eventual distribution of the yeast to people,” Prof. Pohl-Albertyn noted. In countries where locusts are consumed by humans, direct transmission could be more likely.
This research contributes to understanding the natural hosts of emerging pathogens and their role in spreading these diseases. Prof. Pohl-Albertyn emphasized the importance of understanding how C. auris emerged as a pathogen in multiple countries and how environmental factors may have shaped its evolution. “This has implications for the prevention of the spread of this specific yeast species, as well as our preparedness for new pathogenic yeasts that may be emerging from the environment,” she concluded.
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